J
Jun-Ho Choe
Researcher at Samsung Medical Center
Publications - 140
Citations - 6044
Jun-Ho Choe is an academic researcher from Samsung Medical Center. The author has contributed to research in topics: Thyroidectomy & Neck dissection. The author has an hindex of 34, co-authored 136 publications receiving 4368 citations. Previous affiliations of Jun-Ho Choe include Korea University & Boston Children's Hospital.
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Journal ArticleDOI
The m(6)A Methyltransferase METTL3 Promotes Translation in Human Cancer Cells.
Shuibin Lin,Shuibin Lin,Jun-Ho Choe,Jun-Ho Choe,Peng Du,Peng Du,Robinson Triboulet,Robinson Triboulet,Richard I. Gregory +8 more
TL;DR: It is found that METTL3 promotes translation of certain mRNAs including epidermal growth factor receptor (EGFR) and the Hippo pathway effector TAZ in human cancer cells.
Journal ArticleDOI
mRNA circularization by METTL3–eIF3h enhances translation and promotes oncogenesis
Jun-Ho Choe,Shuibin Lin,Shuibin Lin,Shuibin Lin,Wen Cai Zhang,Qi Liu,Qi Liu,Longfei Wang,Julia Ramírez-Moya,Julia Ramírez-Moya,Peng Du,Peng Du,Wantae Kim,Shaojun Tang,Piotr Sliz,Pilar Santisteban,Rani E. George,William G. Richards,Kwok-Kin Wong,Nicolas Locker,Frank J. Slack,Frank J. Slack,Richard I. Gregory +22 more
TL;DR: It is shown that METTL3 enhances translation only when tethered to reporter mRNA at sites close to the stop codon, supporting a mechanism of mRNA looping for ribosome recycling and translational control.
Journal ArticleDOI
Targeting the RNA m6A Reader YTHDF2 Selectively Compromises Cancer Stem Cells in Acute Myeloid Leukemia.
Jasmin Paris,Jasmin Paris,Marcos Morgan,Joana Campos,Joana Campos,Gary J. Spencer,Alena Shmakova,Ivayla Ivanova,Christopher Mapperley,Hannah Lawson,Hannah Lawson,David Wotherspoon,David Wotherspoon,Catarina Sepulveda,Milica Vukovic,Lewis Allen,Annika Sarapuu,Annika Sarapuu,Andrea Tavosanis,Amelie V. Guitart,Arnaud Villacreces,Christian Much,Jun-Ho Choe,Ali Anvari Azar,Ali Anvari Azar,Louie N. van de Lagemaat,Louie N. van de Lagemaat,Douglas Vernimmen,Ali Nehme,Frédéric Mazurier,Tim C. P. Somervaille,Richard I. Gregory,Dónal O'Carroll,Kamil R. Kranc,Kamil R. Kranc +34 more
TL;DR: It is shown that the mRNA m6A reader YTHDF2 is overexpressed in a broad spectrum of human AML and is required for disease initiation as well as propagation in mouse andhuman AML, and identified as a unique therapeutic target whose inhibition selectively targets LSCs while promoting HSC expansion.
Journal ArticleDOI
Mettl1/Wdr4-Mediated m7G tRNA Methylome Is Required for Normal mRNA Translation and Embryonic Stem Cell Self-Renewal and Differentiation.
Shuibin Lin,Qi Liu,Victor S. Lelyveld,Jun-Ho Choe,Jun-Ho Choe,Jack W. Szostak,Richard I. Gregory +6 more
TL;DR: The complexity of the mammalian m7G tRNA methylome is uncovers and its essential role in ESCs with links to human disease is highlighted.
Journal ArticleDOI
LIN28A Is a Suppressor of ER-Associated Translation in Embryonic Stem Cells
Jun Cho,Hyeshik Chang,S. Chul Kwon,Baekgyu Kim,Yoosik Kim,Jun-Ho Choe,Minju Ha,Yoon Ki Kim,V. Narry Kim +8 more
TL;DR: A genome-wide view of the molecular function of LIN28A in mouse embryonic stem cells is obtained by carrying out RNA crosslinking-immunoprecipitation-sequencing (CLIP-seq) and ribosome footprinting and it is found that, in addition to let-7 precursors,LIN28A binds to a large number of spliced mRNAs.