Y
Yoon Ki Kim
Researcher at Korea University
Publications - 104
Citations - 6361
Yoon Ki Kim is an academic researcher from Korea University. The author has contributed to research in topics: Translation (biology) & Nonsense-mediated decay. The author has an hindex of 40, co-authored 96 publications receiving 5284 citations. Previous affiliations of Yoon Ki Kim include University of Rochester & Nagoya City University.
Papers
More filters
Journal ArticleDOI
Mammalian Staufen1 recruits Upf1 to specific mRNA 3'UTRs so as to elicit mRNA decay.
TL;DR: An mRNA decay mechanism that involves Stau1, the NMD factor Upf1, and a termination codon is described, suggesting that Arf1 mRNA is a natural target for Stau2-mediated decay, and data indicate that other mRNAs are also natural targets.
Journal ArticleDOI
Endoribonucleolytic Cleavage of m6A-Containing RNAs by RNase P/MRP Complex.
TL;DR: In this paper, the authors show that m6A-containing RNAs are subject to endoribonucleolytic cleavage via YTHDF2 (m6A reader protein), HRSP12 (adaptor protein), and RNase P/MRP (endoribon nucleases) via endore-ibonuclear cleavage.
Journal ArticleDOI
Upf1 Phosphorylation Triggers Translational Repression during Nonsense-Mediated mRNA Decay
TL;DR: A critical step during NMD is uncovered that converts a pioneer translation initiation complex to a translationally compromised mRNP, and it is shown that phospho-Upf1 functions after nonsense codon recognition during steps that involve the translation initiation factor eIF3 and mRNA decay factors.
Journal ArticleDOI
Quantitative microarray profiling provides evidence against widespread coupling of alternative splicing with nonsense-mediated mRNA decay to control gene expression
Qun Pan,Arneet L. Saltzman,Yoon Ki Kim,Christine M. Misquitta,Ofer Shai,Lynne E. Maquat,Brendan J. Frey,Benjamin J. Blencowe +7 more
TL;DR: Using AS microarrays, it is shown that PTC-containing splice variants are generally produced at uniformly low levels across diverse mammalian cells and tissues, independently of the action of NMD.
Journal ArticleDOI
LIN28A Is a Suppressor of ER-Associated Translation in Embryonic Stem Cells
Jun Cho,Hyeshik Chang,S. Chul Kwon,Baekgyu Kim,Yoosik Kim,Jun-Ho Choe,Minju Ha,Yoon Ki Kim,V. Narry Kim +8 more
TL;DR: A genome-wide view of the molecular function of LIN28A in mouse embryonic stem cells is obtained by carrying out RNA crosslinking-immunoprecipitation-sequencing (CLIP-seq) and ribosome footprinting and it is found that, in addition to let-7 precursors,LIN28A binds to a large number of spliced mRNAs.