L
Louie N. van de Lagemaat
Researcher at University of Edinburgh
Publications - 29
Citations - 5582
Louie N. van de Lagemaat is an academic researcher from University of Edinburgh. The author has contributed to research in topics: Gene & Endogenous retrovirus. The author has an hindex of 20, co-authored 27 publications receiving 4647 citations. Previous affiliations of Louie N. van de Lagemaat include University of British Columbia & BC Cancer Agency.
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Journal ArticleDOI
An anatomically comprehensive atlas of the adult human brain transcriptome
Michael Hawrylycz,Ed S. Lein,Angela L. Guillozet-Bongaarts,Elaine H. Shen,Lydia Ng,Jeremy A. Miller,Louie N. van de Lagemaat,Kimberly A. Smith,Amanda Ebbert,Zackery L. Riley,Chris Abajian,Christian F. Beckmann,Amy Bernard,Darren Bertagnolli,Andrew F. Boe,Preston M. Cartagena,M. Mallar Chakravarty,Mike Chapin,Jimmy Chong,Rachel A. Dalley,Barry Daly,Chinh Dang,Suvro Datta,Nick Dee,Tim A. Dolbeare,Vance Faber,David Feng,David R. Fowler,Jeff Goldy,Benjamin W. Gregor,Zeb Haradon,David R. Haynor,John G. Hohmann,Steve Horvath,Robert Howard,Andreas Jeromin,Jayson M. Jochim,Marty Kinnunen,Christopher Lau,Evan T. Lazarz,Changkyu Lee,Tracy Lemon,Ling Li,Yang Li,John A. Morris,Caroline C. Overly,Patrick D. Parker,Sheana Parry,Melissa Reding,Joshua J. Royall,Jay Schulkin,Pedro Adolfo Sequeira,Clifford R. Slaughterbeck,Simon Smith,Andy J. Sodt,Susan M. Sunkin,Beryl Swanson,Marquis P. Vawter,Derric Williams,Paul Wohnoutka,H. Ronald Zielke,Daniel H. Geschwind,Patrick R. Hof,Stephen M. Smith,Christof Koch,Seth G. N. Grant,Allan R. Jones +66 more
TL;DR: A transcriptional atlas of the adult human brain is described, comprising extensive histological analysis and comprehensive microarray profiling of ∼900 neuroanatomically precise subdivisions in two individuals, to form a high-resolution transcriptional baseline for neurogenetic studies of normal and abnormal human brain function.
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Characterization of the proteome, diseases and evolution of the human postsynaptic density
Àlex Bayés,Louie N. van de Lagemaat,Mark O. Collins,Mike D. R. Croning,Ian R. Whittle,Jyoti S. Choudhary,Seth G. N. Grant +6 more
TL;DR: The postsynaptic density from human neocortex (hPSD) was isolated and 1,461 proteins were identified that were enriched in cognitive, affective and motor phenotypes underpinned by sets of genes.
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Transposable elements in mammals promote regulatory variation and diversification of genes with specialized functions
TL;DR: Evidence is found suggesting that TEs affect the expression of many genes through the donation of transcriptional regulatory signals, and that recently expanded gene classes, such as those involved in immunity or response to external stimuli, have transcripts enriched in TEs.
Journal ArticleDOI
Retroviral elements and their hosts: insertional mutagenesis in the mouse germ line.
Irina A. Maksakova,Mark T. Romanish,Liane Gagnier,Catherine A. Dunn,Louie N. van de Lagemaat,Dixie L. Mager +5 more
TL;DR: The prevalence of mouse ERV activity indicates that the genome of the laboratory mouse is presently behind in the “arms race” against invasion.
Journal ArticleDOI
Retroelement distributions in the human genome: variations associated with age and proximity to genes.
TL;DR: It is shown that genomic densities of 10 major classes of human retroelements are distributed differently with respect to surrounding GC content and also show that the oldest elements are preferentially found in regions of lower GC compared with their younger relatives.