Jun Hyoung Park

TL;DR: Analysis of cybrids and established breast cancer cell lines showed that metastatic TNBC maintains high levels of ATP through fatty acid β oxidation (FAO) and activates Src oncoprotein through autophosphorylation at Y419, and confirmed the role of mitochondrial FAO in Src activation and metastasis.

TL;DR: The experimental results confirm that TNBC cells can maintain a hybrid metabolic phenotype and targeting both glycolysis and OXPHOS is necessary to eliminate their metabolic plasticity, and the theoretical framework to decode the coupling of gene regulation and metabolic pathways is established.

TL;DR: Emerging evidence shows that cancer cells can acquire a hybrid glycolysis/OXPHOS phenotype in which both glyCOlysis and OXPHOS can be utilized for energy production and biomass synthesis, and may be specifically associated with metastasis and therapy-resistance.

TL;DR: The results suggest the critical oncogenic regulation by mitochondrial-nuclear cross talk and highlights rectifying mitochondrial functional properties as a promising target in cancer therapy.

TL;DR: In obese elderly, combined aerobic and resistance exercise is superior to either mode independently for improving muscle protein synthesis and myocellular quality, thereby maintaining muscle mass during weight-loss therapy.