J
Jürgen Deckert
Researcher at University of Würzburg
Publications - 319
Citations - 12655
Jürgen Deckert is an academic researcher from University of Würzburg. The author has contributed to research in topics: Panic disorder & Anxiety. The author has an hindex of 52, co-authored 300 publications receiving 10227 citations. Previous affiliations of Jürgen Deckert include University of Innsbruck & Museum für Naturkunde.
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Journal ArticleDOI
Systematic mutation screening and association study of the A1 and A2a adenosine receptor genes in panic disorder suggest a contribution of the A2a gene to the development of disease.
Jürgen Deckert,Markus M. Nöthen,Petra Franke,Cynthia D. Delmo,Jürgen Fritze,Michael Knapp,Wolfgang Maier,Helmut Beckmann,Peter Propping +8 more
TL;DR: The findings lend further support to the hypothesis that the A2aAR gene, or a locus in linkage disequilibrium with it, confers susceptibility to panic disorder.
Journal ArticleDOI
TMEM132D, a new candidate for anxiety phenotypes: evidence from human and mouse studies.
Angelika Erhardt,L. Czibere,D. Roeske,Susanne Lucae,Paul G. Unschuld,Stephan Ripke,Michael Specht,Martin A. Kohli,Stefan Kloiber,Marcus Ising,Angela Heck,Hildegard Pfister,Petra Zimmermann,Roselind Lieb,Benno Pütz,Manfred Uhr,Peter Weber,Jan M. Deussing,Mariya Gonik,Mirjam Bunck,Melanie S. Kessler,Elisabeth Frank,Christa Hohoff,Katharina Domschke,Petra Krakowitzky,Wolfgang Maier,Borwin Bandelow,Christian Jacob,Jürgen Deckert,Stefan Schreiber,Jana Strohmaier,Markus M. Nöthen,Sven Cichon,M. Rietschel,Thomas Bettecken,Martin E. Keck,Rainer Landgraf,Bertram Müller-Myhsok,Florian Holsboer,Elisabeth B. Binder +39 more
TL;DR: Using a mouse model of extremes in trait anxiety, it is shown that anxiety-related behavior was positively correlated with Tmem132d mRNA expression in the anterior cingulate cortex, central to the processing of anxiety/fear-related stimuli, and that in this animal model a T Mem132d SNP is associated with anxiety- related behavior in an F2 panel.
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Association of the functional V158M catechol- O -methyl-transferase polymorphism with panic disorder in women
Katharina Domschke,Christine M. Freitag,Gregor Kuhlenbäumer,Anja Schirmacher,Philipp G. Sand,Peter Nyhuis,Christian Jacob,Jürgen Fritze,Petra Franke,Marcella Rietschel,Henk S.P. Garritsen,Rolf Fimmers,Markus M. Nöthen,Klaus-Peter Lesch,Florian Stögbauer,Jürgen Deckert +15 more
TL;DR: The genotyping of a single nucleotide polymorphism in the coding region of the catechol-O-methyl-transferase (COMT) gene supports a role of the 472G/A (V158M) COMT polymorphism or a nearby locus in the pathogenesis of panic disorder in women.
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Association of the COMT val158met variant with antidepressant treatment response in major depression.
Bernhard T. Baune,Bernhard T. Baune,Christa Hohoff,Klaus Berger,Anna Neumann,Sünke Mortensen,Tilmann Roehrs,Jürgen Deckert,Volker Arolt,Katharina Domschke +9 more
TL;DR: The present results strongly point toward a negative influence of the higher activity COMT 158val/val genotype on antidepressant treatment response during the first 6 weeks of pharmacological treatment in major depression, possibly conferred by consecutively decreased dopamine availability.
Journal ArticleDOI
Oxytocin Receptor Gene Methylation: Converging Multilevel Evidence for a Role in Social Anxiety
Christiane Ziegler,Udo Dannlowski,David Bräuer,Stephan Stevens,Inga Laeger,Hannah Wittmann,Harald Kugel,Christian Dobel,René Hurlemann,Andreas Reif,Klaus-Peter Lesch,Walter Heindel,Clemens Kirschbaum,Volker Arolt,Alexander L. Gerlach,Jürgen Hoyer,Jürgen Deckert,Peter Zwanzger,Katharina Domschke +18 more
TL;DR: OXTR methylation patterns might thus serve as peripheral surrogates of oxytocin tone and aid in establishing accessible biomarkers of SAD risk allowing for indicated preventive interventions and personalized treatment approaches targeting the Oxytocin system.