J
Jurgen Herre
Researcher at Cambridge University Hospitals NHS Foundation Trust
Publications - 43
Citations - 2941
Jurgen Herre is an academic researcher from Cambridge University Hospitals NHS Foundation Trust. The author has contributed to research in topics: Computer science & Innate immune system. The author has an hindex of 12, co-authored 29 publications receiving 2638 citations. Previous affiliations of Jurgen Herre include University of Cambridge & University of Oxford.
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Journal ArticleDOI
Dectin-1 Mediates the Biological Effects of β-Glucans
Gordon D. Brown,Jurgen Herre,David L. Williams,Janet A. Willment,Andrew S J Marshall,Siamon Gordon +5 more
TL;DR: It is shown that Dectin-1 mediates the production of TNF-α in response to zymosan and live fungal pathogens, an activity that occurs at the cell surface and requires the cytoplasmic tail and immunoreceptor tyrosine activation motif of Dect in addition to Toll-like receptor (TLR)-2 and Myd88.
Journal ArticleDOI
Dectin-1 uses novel mechanisms for yeast phagocytosis in macrophages
Jurgen Herre,Andrew S J Marshall,Emmanuelle Caron,Alexander D. Edwards,David L. Williams,Edina Schweighoffer,Victor L. J. Tybulewicz,Caetano Reis e Sousa,Siamon Gordon,Gordon D. Brown +9 more
TL;DR: Dectin-1, a proinflammatory nonopsonic receptor for beta-glucans, is examined, and it is shown that it mediates the internalization of beta- glucan-bearing ligands, including yeast particles.
Journal ArticleDOI
Dectin-1 and its role in the recognition of β-glucans by macrophages
TL;DR: It is shown that Dectin-1, a murine type II C-type lectin-like receptor, was able to non-opsonically recognize β- 1,3 and β-2,6 linked glucan rich particles and intact yeast.
Journal ArticleDOI
The role of SIGNR1 and the beta-glucan receptor (dectin-1) in the nonopsonic recognition of yeast by specific macrophages.
Philip R. Taylor,Gordon D. Brown,Jurgen Herre,David L. Williams,Janet A. Willment,Siamon Gordon +5 more
TL;DR: This study has studied the mannose-binding potential of murine Mφ and identified the dendritic cell-specific ICAM-3-grabbing nonintegrin homolog, SIGN-related 1 (SIGNR1), as a major MR on murine resident peritoneal M φ.
Journal ArticleDOI
Outpatient Talc Administration by Indwelling Pleural Catheter for Malignant Effusion
Rahul Bhatnagar,Emma Keenan,Anna J Morley,Brennan C Kahan,Andrew E. Stanton,Mohammed Haris,Richard Harrison,Rehan A. Mustafa,Lesley Bishop,Liju Ahmed,Alex West,J Holme,Matthew Evison,Mohammed Munavvar,Pasupathy Sivasothy,Jurgen Herre,David Cooper,Mark Roberts,Anur Guhan,Clare E Hooper,James R. Walters,Tarek Saba,Biswajit Chakrabarti,Samal Gunatilake,Ioannis Psallidas,Steven Walker,Anna C. Bibby,Sarah Smith,Louise Stadon,Natalie Zahan-Evans,Y. C. Gary Lee,John E Harvey,Najib M. Rahman,Robert F. Miller,Nick A Maskell +34 more
TL;DR: Among patients without substantial lung entrapment, the outpatient administration of talc through an indwelling pleural catheter for the treatment of malignant pleural effusion resulted in a significantly higher chance of pleurodesis at 35 days than an ind welling catheter alone, with no deleterious effects.