J
Jürgen M. Lehmann
Researcher at Research Triangle Park
Publications - 56
Citations - 23022
Jürgen M. Lehmann is an academic researcher from Research Triangle Park. The author has contributed to research in topics: Receptor & Peroxisome proliferator-activated receptor. The author has an hindex of 41, co-authored 56 publications receiving 22350 citations. Previous affiliations of Jürgen M. Lehmann include Ludwig Maximilian University of Munich & National Foundation for Cancer Research.
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Journal ArticleDOI
An Antidiabetic Thiazolidinedione Is a High Affinity Ligand for Peroxisome Proliferator-activated Receptor γ (PPARγ)
Jürgen M. Lehmann,Linda B. Moore,Tracey Smith-Oliver,William O. Wilkison,Timothy M. Willson,Steven A. Kliewer +5 more
TL;DR: It is reported that thiazolidinediones are potent and selective activators of peroxisome proliferator-activated receptor γ (PPARγ), a member of the nuclear receptor superfamily recently shown to function in adipogenesis, and raised the intriguing possibility that PPARγ is a target for the therapeutic actions of this class of compounds.
Journal ArticleDOI
A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor γ and promotes adipocyte differentiation
Steven A. Kliewer,James M. Lenhard,Timothy M. Willson,Inder Patel,David C. Morris,Jürgen M. Lehmann +5 more
TL;DR: The PGJ2 and its derivatives are efficacious activators of peroxisome proliferator-activated receptors alpha and gamma (PPAR alpha and PPAR gamma, respectively), orphan nuclear receptors implicated in lipid homeostasis and adipocyte differentiation and suggest a novel mechanism of action for PGs of the J2 series.
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Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors α and γ
Steven A. Kliewer,Scott S. Sundseth,Stacey A. Jones,Peter Brown,G. Bruce Wisely,Cecilia S. Koble,Pallavi R. Devchand,Walter Wahli,Timothy M. Willson,James M. Lenhard,Jürgen M. Lehmann +10 more
TL;DR: Evidence that PPARs serve as physiological sensors of lipid levels is provided and a molecular mechanism whereby dietary fatty acids can modulate lipid homeostasis is suggested.
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Bile Acids: Natural Ligands for an Orphan Nuclear Receptor
Derek J. Parks,Steven G. Blanchard,Randy K. Bledsoe,Gyan Chandra,Thomas G. Consler,Steven A. Kliewer,Julie B. Stimmel,Timothy M. Willson,Ann Marie Zavacki,David D. Moore,Jürgen M. Lehmann +10 more
TL;DR: Results provide evidence for a nuclear bile acid signaling pathway that may regulate cholesterol homeostasis and modulated interaction of FXR with a peptide derived from steroid receptor coactivator 1.
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The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions.
Jürgen M. Lehmann,David D. McKee,Michael A. Watson,Timothy M. Willson,John T. Moore,Steven A. Kliewer +5 more
TL;DR: The identification of a human (h) orphan nuclear receptor, termed the pregnane X receptor (PXR), that binds to a response element in the CYP3A4 promoter and is activated by a range of drugs known to induce CYP 3A4 expression is reported.