M
Mitchell V. Hull
Researcher at Scripps Health
Publications - 23
Citations - 1517
Mitchell V. Hull is an academic researcher from Scripps Health. The author has contributed to research in topics: Chemistry & Granulomatous amoebic encephalitis. The author has an hindex of 12, co-authored 23 publications receiving 1004 citations. Previous affiliations of Mitchell V. Hull include Torrey Pines Institute for Molecular Studies.
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Journal ArticleDOI
Discovery of SARS-CoV-2 antiviral drugs through large-scale compound repurposing.
Laura Riva,Shuofeng Yuan,Xin Yin,Laura Martin-Sancho,Naoko Matsunaga,Lars Pache,Sebastian Burgstaller-Muehlbacher,Paul D. De Jesus,Peter Teriete,Mitchell V. Hull,Max W. Chang,Jasper Fuk-Woo Chan,Jianli Cao,Vincent Kwok-Man Poon,Kristina M. Herbert,Kuoyuan Cheng,Kuoyuan Cheng,Tu Trinh H. Nguyen,Andrey Rubanov,Yuan Pu,Courtney Nguyen,Angela Choi,Raveen Rathnasinghe,Michael Schotsaert,Lisa Miorin,Marion Dejosez,Thomas P. Zwaka,Ko Yung Sit,Luis Martinez-Sobrido,Wen-Chun Liu,Kris M. White,Mackenzie E. Chapman,Emma K. Lendy,Richard Glynne,Randy A. Albrecht,Eytan Ruppin,Andrew D. Mesecar,Jeffrey R Johnson,Christopher Benner,Ren Sun,Peter G. Schultz,Andrew I. Su,Adolfo García-Sastre,Arnab K. Chatterjee,Kwok-Yung Yuen,Sumit K. Chanda +45 more
TL;DR: A screen of the ReFRAME library of approximately 12,000 known drugs for antiviral activity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) identified several candidate compounds with suitable activities and pharmacological profiles, which could potentially expedite the deployment of therapies for coronav virus disease 2019 (COVID-19).
Journal ArticleDOI
4-Hydroxytamoxifen binds to and deactivates the estrogen-related receptor gamma.
TL;DR: The results demonstrate the existence of high-affinity ligands for the ERR family of orphan receptors, and identify 4-OHT as a molecule that can regulate the transcriptional activity of ERRγ.
Journal ArticleDOI
The ReFRAME library as a comprehensive drug repurposing library and its application to the treatment of cryptosporidiosis.
Jeff Janes,Megan E Young,Emily I. Chen,Nicole H Rogers,Sebastian Burgstaller-Muehlbacher,Laura D. Hughes,Melissa S. Love,Mitchell V. Hull,Kelli Kuhen,Ashley K. Woods,Sean B. Joseph,H. Michael Petrassi,Case W. McNamara,Matthew S. Tremblay,Andrew I. Su,Peter G. Schultz,Arnab Chatterjee +16 more
TL;DR: A comprehensive open-access, drug repositioning screening set of 12,000 compounds that was assembled by combining three widely used commercial drug competitive intelligence databases, together with extensive patent mining of small molecules that have been dosed in humans.
Journal ArticleDOI
Screening the mammalian extracellular proteome for regulators of embryonic human stem cell pluripotency
Rodolfo Gonzalez,Lori L. Jennings,Mark W. Knuth,Anthony P. Orth,Heath E. Klock,Weija Ou,Julie Feuerhelm,Mitchell V. Hull,Eric Koesema,Yuping Wang,Jia Zhang,Chunlei Wu,Charles Y. Cho,Andrew I. Su,Serge Batalov,Hong Chen,Kristen Johnson,Bryan A. Laffitte,Deborah G. Nguyen,Evan Y. Snyder,Peter G. Schultz,Jennifer L. Harris,Scott A. Lesley +22 more
TL;DR: It is found that the pigment epithelium-derived factor can promote long-term pluripotent growth of human embryonic stem cells without bFGF or TGFβ/Activin/Nodal ligand supplementation.
Journal ArticleDOI
Sulfur(VI) Fluoride Exchange (SuFEx)-Enabled High-Throughput Medicinal Chemistry
Seiya Kitamura,Qinheng Zheng,Jordan L. Woehl,Angelo Solania,Emily I. Chen,Nicholas Dillon,Mitchell V. Hull,Miyako Kotaniguchi,John R. Cappiello,Shinichi Kitamura,Victor Nizet,K. Barry Sharpless,Dennis W. Wolan +12 more
TL;DR: A high-throughput hit-to-lead process based on the biocompatible SuFEx click chemistry that succeeds on picomole scale for direct screening and can accelerate the development of robust biological probes and drug candidates is demonstrated.