T
Tobias J. Tuthill
Researcher at Institute for Animal Health
Publications - 26
Citations - 1090
Tobias J. Tuthill is an academic researcher from Institute for Animal Health. The author has contributed to research in topics: Virus & Picornavirus. The author has an hindex of 14, co-authored 18 publications receiving 989 citations. Previous affiliations of Tobias J. Tuthill include University of Leeds.
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Journal ArticleDOI
Mouse models of rhinovirus-induced disease and exacerbation of allergic airway inflammation
Nathan W. Bartlett,Ross P. Walton,Michael R. Edwards,Juliya Aniscenko,Gaetano Caramori,Jie Zhu,Nicholas Glanville,Katherine Choy,Patrick Jourdan,Jerome Burnet,Tobias J. Tuthill,Michael S Pedrick,Michael Hurle,Chris Plumpton,Nigel A. Sharp,James N Bussell,Dallas M. Swallow,Jürgen Schwarze,Bruno Guy,Jeffrey Almond,Peter K. Jeffery,Clare M. Lloyd,Alberto Papi,R. A. Killington,David J. Rowlands,Edward D. Blair,Neil J. Clarke,Sebastian L. Johnston +27 more
TL;DR: Three novel mouse models of rhinovirus infection have features similar to those observed in rhinvirus infection in humans, including augmentation of allergic airway inflammation, and will be useful in the development of future therapies for colds and asthma exacerbations.
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Characterization of Early Steps in the Poliovirus Infection Process: Receptor-Decorated Liposomes Induce Conversion of the Virus to Membrane-Anchored Entry-Intermediate Particles
TL;DR: The generation of a receptor-decorated liposome system, comprising nickel-chelating nitrilotriacetic acid (NTA) liposomes and His-tagged poliovirus receptor, and its use in characterizing the early events in poliov virus infection is described.
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A plate-based high-throughput assay for virus stability and vaccine formulation.
Thomas S. Walter,Jingshan Ren,Tobias J. Tuthill,David J. Rowlands,David I. Stuart,Elizabeth E. Fry +5 more
TL;DR: This work presents a plate-based assay for virus measuring virus stability that facilitates the dissection of virus uncoating and a fast and efficient high-throughput method to optimise vaccine formulation.
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Capsid protein VP4 of human rhinovirus induces membrane permeability by the formation of a size-selective multimeric pore.
Anusha Panjwani,Mike Strauss,Sarah Gold,Hannah Wenham,Terry Jackson,James J. Chou,David J. Rowlands,Nicola J. Stonehouse,James M. Hogle,Tobias J. Tuthill +9 more
TL;DR: The recombinant C-terminal histidine-tagged human rhinovirus VP4 is produced and shown it can induce membrane permeability in liposome model membranes and provide a model system which will facilitate exploration of VP4 as a novel antiviral target for the picornavirus family.
Journal ArticleDOI
Inhibition of hepatitis C virus p7 membrane channels in a liposome-based assay system.
TL;DR: This system provides the first convenient in vitro assay for exploiting p7 as a therapeutic target and demonstrates that activity is due to the formation of a size-selective pore rather than non-specific disruption of liposomes and that activity can be blocked by amantadine and several other compounds.