J
Justin Hanes
Researcher at Johns Hopkins University
Publications - 298
Citations - 27850
Justin Hanes is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Drug delivery & Mucus. The author has an hindex of 75, co-authored 288 publications receiving 23760 citations. Previous affiliations of Justin Hanes include Massachusetts Institute of Technology & University of Alberta.
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PEGylation as a strategy for improving nanoparticle-based drug and gene delivery
TL;DR: The history of the development of PEGylated nanoparticle formulations for systemic administration is described, including how factors such as PEG molecular weight, PEG surface density, nanoparticle core properties, and repeated administration impact circulation time.
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Mucus-penetrating nanoparticles for drug and gene delivery to mucosal tissues.
TL;DR: The tenacious mucus barrier properties that have precluded the efficient penetration of therapeutic particles are described and the design and development of new mucus-penetrating particles that may avoid rapid mucus clearance mechanisms are reviewed to provide targeted or sustained drug delivery for localized therapies in mucosal tissues.
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Oral drug delivery with polymeric nanoparticles: the gastrointestinal mucus barriers.
TL;DR: The protective barrier properties of mucus secretions, how mucus affects the fate of orally administered nanoparticles, and recent developments in nanoparticles engineered to penetrate the mucus barrier are addressed.
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Large Porous Particles for Pulmonary Drug Delivery
David A. Edwards,Justin Hanes,Giovanni Caponetti,Jeffrey S. Hrkach,Abdellaziz Ben-Jebria,Mary Lou Eskew,Jeffrey Mintzes,Daniel R. Deaver,Noah Lotan,Robert Langer +9 more
TL;DR: A new type of inhalation aerosol, characterized by particles of small mass density and large size, permitted the highly efficient delivery of inhaled therapeutics into the systemic circulation.
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Rapid transport of large polymeric nanoparticles in fresh undiluted human mucus
Samuel K. Lai,D. Elizabeth O'Hanlon,Suzanne Harrold,Stan T. Man,Ying Ying Wang,Richard A. Cone,Justin Hanes +6 more
TL;DR: It is demonstrated that large nanoparticles, if properly coated, can rapidly penetrate physiological human mucus, and they offer the prospect thatLarge nanoparticles can be used for mucosal drug delivery.