J
Justin Tan
Researcher at University of California, San Diego
Publications - 22
Citations - 1321
Justin Tan is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Oxidative stress & Receptor tyrosine kinase. The author has an hindex of 13, co-authored 21 publications receiving 1047 citations. Previous affiliations of Justin Tan include University of California, Berkeley.
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Journal ArticleDOI
Nonalcoholic Fatty Liver Disease: MR Imaging of Liver Proton Density Fat Fraction to Assess Hepatic Steatosis
An Tang,Justin Tan,Mark Sun,Gavin Hamilton,Mark Bydder,Tanya Wolfson,Anthony Gamst,Michael S. Middleton,Elizabeth M. Brunt,Rohit Loomba,Joel E. Lavine,Jeffrey B. Schwimmer,Claude B. Sirlin +12 more
TL;DR: MR imaging-PDFF showed promise for assessment of hepatic steatosis grade in patients with NAFLD, and was significantly correlated with histologic steatotic grade.
Journal ArticleDOI
Supplementation of Saturated Long-Chain Fatty Acids Maintains Intestinal Eubiosis and Reduces Ethanol-induced Liver Injury in Mice
Peng Chen,Manolito Torralba,Justin Tan,Mallory Embree,Karsten Zengler,Peter Stärkel,Jan-Peter van Pijkeren,Jessica DePew,Rohit Loomba,Samuel B. Ho,Samuel B. Ho,Jasmohan S. Bajaj,Ece Mutlu,Ali Keshavarzian,Hidekazu Tsukamoto,Karen E. Nelson,Derrick E. Fouts,Bernd Schnabl +17 more
TL;DR: In humans and mice, alcohol causes intestinal dysbiosis, reducing the capacity of the microbiome to synthesize saturated LCFA and the proportion of Lactobacillus species, which might reduce ethanol-induced liver injury in patients with alcoholic liver disease.
Journal ArticleDOI
Multi-omic data integration enables discovery of hidden biological regularities
Ali Ebrahim,Elizabeth Brunk,Elizabeth Brunk,Justin Tan,Edward J. O’Brien,Donghyuk Kim,Richard Szubin,Joshua A. Lerman,Anna Lechner,Anand V. Sastry,Aarash Bordbar,Adam M. Feist,Adam M. Feist,Bernhard O. Palsson +13 more
TL;DR: Advanced data integration methods for multi-level analysis of genomic, transcriptomic, ribosomal profiling, proteomic and fluxomic data are developed, showing that pairwise integration of primary omics data reveals regularities that tie cellular processes together in Escherichia coli.
Journal ArticleDOI
Global transcriptional regulatory network for Escherichia coli robustly connects gene expression to transcription factor activities
Xin Fang,Anand V. Sastry,Nathan Mih,Donghyuk Kim,Justin Tan,James T. Yurkovich,Colton J. Lloyd,Ye Gao,Laurence Yang,Bernhard O. Palsson,Bernhard O. Palsson +10 more
TL;DR: A high-confidence TRN is reconstructed, its consistency with transcriptomics and predictive capabilities across multiple conditions is determined, and 10 regulatory modules whose definitions were robust against changes to the TRN or expression compendium are identified.
Journal ArticleDOI
Cellular responses to reactive oxygen species are predicted from molecular mechanisms
Laurence Yang,Nathan Mih,Amitesh Anand,Joon Ho Park,Justin Tan,James T. Yurkovich,Jonathan M. Monk,Colton J. Lloyd,Troy E. Sandberg,Sang Woo Seo,Donghyuk Kim,Anand V. Sastry,Patrick V. Phaneuf,Ye Gao,Jared T. Broddrick,Ke Chen,David Heckmann,Richard Szubin,Ying Hefner,Adam M. Feist,Adam M. Feist,Bernhard O. Palsson,Bernhard O. Palsson +22 more
TL;DR: A computable multiscale description of the ROS stress response in Escherichia coli is developed, called OxidizeME, which shows that fundamental and quantitative genotype–phenotype relationships for stress responses on a genome-wide basis are developed.