J
Jared T. Broddrick
Researcher at University of California, San Diego
Publications - 18
Citations - 557
Jared T. Broddrick is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Metabolic network & Phaeodactylum tricornutum. The author has an hindex of 10, co-authored 15 publications receiving 363 citations. Previous affiliations of Jared T. Broddrick include Ames Research Center & University of California, Berkeley.
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Journal ArticleDOI
Unique attributes of cyanobacterial metabolism revealed by improved genome-scale metabolic modeling and essential gene analysis.
Jared T. Broddrick,Benjamin E. Rubin,David G. Welkie,Niu Du,Nathan Mih,Spencer Diamond,Jenny J. Lee,Susan S. Golden,Bernhard O. Palsson +8 more
TL;DR: A experimentally validated and manually curated model of metabolism in Synechococcus elongatus PCC 7942 is presented that leads to discovery of unique metabolic characteristics, highlights poorly understood areas of metabolism, and highlights previously unknown areas of S. elongatus biology.
Journal ArticleDOI
Genome-Scale Model Reveals Metabolic Basis of Biomass Partitioning in a Model Diatom
Jennifer Levering,Jared T. Broddrick,Christopher L. Dupont,Graham Peers,Karen Beeri,Joshua Mayers,Alessandra A. Gallina,Andrew E. Allen,Andrew E. Allen,Bernhard O. Palsson,Karsten Zengler +10 more
TL;DR: A genome-scale metabolic network reconstruction for the marine diatom Phaeodactylum tricornutum is performed and the presence of a yet unknown glutamine-ornithine shunt that could be used to transfer reducing equivalents generated by photosynthesis to the mitochondria is indicated.
Journal ArticleDOI
Evolution and regulation of nitrogen flux through compartmentalized metabolic networks in a marine diatom
Sarah R. Smith,Christopher L. Dupont,James K. McCarthy,Jared T. Broddrick,Miroslav Oborník,Miroslav Oborník,Aleš Horák,Aleš Horák,Zoltán Füssy,Zoltán Füssy,Jaromír Cihlář,Jaromír Cihlář,Sabrina Kleessen,Hong Zheng,John P. McCrow,Kim K. Hixson,Wagner L. Araújo,Adriano Nunes-Nesi,Alisdair R. Fernie,Zoran Nikoloski,Bernhard O. Palsson,Andrew E. Allen,Andrew E. Allen +22 more
TL;DR: The authors combine functional genomics, phylogenetics, and metabolic modeling to describe how diatoms might have functionally integrated nitrogen metabolism during evolution and how metabolic flux is regulated across cellular compartments.
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Cellular responses to reactive oxygen species are predicted from molecular mechanisms
Laurence Yang,Nathan Mih,Amitesh Anand,Joon Ho Park,Justin Tan,James T. Yurkovich,Jonathan M. Monk,Colton J. Lloyd,Troy E. Sandberg,Sang Woo Seo,Donghyuk Kim,Anand V. Sastry,Patrick V. Phaneuf,Ye Gao,Jared T. Broddrick,Ke Chen,David Heckmann,Richard Szubin,Ying Hefner,Adam M. Feist,Adam M. Feist,Bernhard O. Palsson,Bernhard O. Palsson +22 more
TL;DR: A computable multiscale description of the ROS stress response in Escherichia coli is developed, called OxidizeME, which shows that fundamental and quantitative genotype–phenotype relationships for stress responses on a genome-wide basis are developed.
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Engineering of oleaginous organisms for lipid production
TL;DR: Recent advances in in vitro, in vivo, and in silico manipulations of phototrophic metabolism that increase total lipid content or redirect lipid production toward more favorable products such as polyunsaturated fatty acids used as nutritional supplements or in biofuel production are described.