P
Peng Chen
Researcher at University of California, San Diego
Publications - 10
Citations - 1530
Peng Chen is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Alcoholic liver disease & Liver disease. The author has an hindex of 9, co-authored 10 publications receiving 1153 citations. Previous affiliations of Peng Chen include Southern Medical University.
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Journal ArticleDOI
Intestinal fungi contribute to development of alcoholic liver disease
An Ming Yang,Tatsuo Inamine,Tatsuo Inamine,Katrin Hochrath,Peng Chen,Lirui Wang,Lirui Wang,Cristina Llorente,Cristina Llorente,Sena Bluemel,Phillipp Hartmann,Jun Xu,Yukinori Koyama,Tatiana Kisseleva,Manolito Torralba,Kelvin J. Moncera,Karen Beeri,Chien Sheng Chen,K Freese,Claus Hellerbrand,Serene M.L. Lee,Hal M. Hoffman,Wajahat Z. Mehal,Guadalupe Garcia-Tsao,Guadalupe Garcia-Tsao,Ece Mutlu,Ali Keshavarzian,Gordon D. Brown,Samuel B. Ho,Samuel B. Ho,Ramon Bataller,Peter Stärkel,Derrick E. Fouts,Bernd Schnabl,Bernd Schnabl +34 more
TL;DR: It is demonstrated that chronic alcohol administration increases mycobiota populations and translocation of fungal &bgr;-glucan into systemic circulation in mice and Manipulating the intestinalMycobiome might be an effective strategy for attenuating alcohol-related liver disease.
Journal ArticleDOI
Intestinal REG3 Lectins Protect against Alcoholic Steatohepatitis by Reducing Mucosa-Associated Microbiota and Preventing Bacterial Translocation
Lirui Wang,Lirui Wang,Derrick E. Fouts,Peter Stärkel,Phillipp Hartmann,Peng Chen,Cristina Llorente,Cristina Llorente,Jessica DePew,Kelvin J. Moncera,Samuel B. Ho,Samuel B. Ho,David A. Brenner,Lora V. Hooper,Lora V. Hooper,Bernd Schnabl,Bernd Schnabl +16 more
TL;DR: It is demonstrated that intestinal deficiency in REG3B or REG3G increases numbers of mucosa-associated bacteria and enhances bacterial translocation to the mesenteric lymph nodes and liver, promoting the progression of ethanol-induced fatty liver disease toward steatohepatitis.
Journal ArticleDOI
Supplementation of Saturated Long-Chain Fatty Acids Maintains Intestinal Eubiosis and Reduces Ethanol-induced Liver Injury in Mice
Peng Chen,Manolito Torralba,Justin Tan,Mallory Embree,Karsten Zengler,Peter Stärkel,Jan-Peter van Pijkeren,Jessica DePew,Rohit Loomba,Samuel B. Ho,Samuel B. Ho,Jasmohan S. Bajaj,Ece Mutlu,Ali Keshavarzian,Hidekazu Tsukamoto,Karen E. Nelson,Derrick E. Fouts,Bernd Schnabl +17 more
TL;DR: In humans and mice, alcohol causes intestinal dysbiosis, reducing the capacity of the microbiome to synthesize saturated LCFA and the proportion of Lactobacillus species, which might reduce ethanol-induced liver injury in patients with alcoholic liver disease.
Journal ArticleDOI
Methods to determine intestinal permeability and bacterial translocation during liver disease.
Lirui Wang,Cristina Llorente,Phillipp Hartmann,An-Ming Yang,Peng Chen,Bernd Schnabl,Bernd Schnabl +6 more
TL;DR: Methods to assess intestinal barrier disruption and measure increased intestinal permeability and bacterial translocation in experimental liver disease models are reviewed and advantages and disadvantages are discussed.
Journal ArticleDOI
Deficiency of intestinal mucin-2 ameliorates experimental alcoholic liver disease in mice
Phillipp Hartmann,Peng Chen,Hui J. Wang,Lirui Wang,Declan F. McCole,Katharina Brandl,Peter Stärkel,Clara Belzer,Claus Hellerbrand,Hidekazu Tsukamoto,Hidekazu Tsukamoto,Samuel B. Ho,Samuel B. Ho,Bernd Schnabl +13 more
TL;DR: Muc2−/− mice are protected from intestinal bacterial overgrowth and dysbiosis in response to alcohol feeding, and lower amounts of bacterial products such as endotoxin translocate into the systemic circulation, decreasing liver disease.