K
K. Hoffman
Researcher at University of Texas MD Anderson Cancer Center
Publications - 6
Citations - 2873
K. Hoffman is an academic researcher from University of Texas MD Anderson Cancer Center. The author has contributed to research in topics: Microbiome & Supine position. The author has an hindex of 4, co-authored 6 publications receiving 1830 citations. Previous affiliations of K. Hoffman include Baylor College of Medicine.
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Journal ArticleDOI
Gut microbiome modulates response to anti–PD-1 immunotherapy in melanoma patients
Vancheswaran Gopalakrishnan,Vancheswaran Gopalakrishnan,Christine N. Spencer,Christine N. Spencer,Luigi Nezi,Alexandre Reuben,Miles C. Andrews,Tatiana Karpinets,Peter A. Prieto,D. Vicente,K. Hoffman,Spencer C. Wei,Alexandria P. Cogdill,Li Zhao,Courtney W. Hudgens,Diane S. Hutchinson,T. Manzo,M. Petaccia de Macedo,Tiziana Cotechini,T. Kumar,Wei Shen Chen,Sangeetha M. Reddy,R. Szczepaniak Sloane,Jessica Galloway-Peña,Hong Jiang,P. L. Chen,Elizabeth J. Shpall,Katayoun Rezvani,Amin M. Alousi,Roy F. Chemaly,Samuel A. Shelburne,Luis M Vence,Pablo C. Okhuysen,V. B. Jensen,Alton G. Swennes,Florencia McAllister,E. Marcelo Riquelme Sanchez,Yu Zhang,Laurence Zitvogel,Nicolas Pons,Jacob Austin-Breneman,Lauren E. Haydu,Elizabeth M. Burton,J. M. Gardner,E. Sirmans,Jing Shan Hu,Alexander J. Lazar,Takahiro Tsujikawa,Adi Diab,Hussein Abdul-Hassan Tawbi,Isabella C. Glitza,Wen-Jen Hwu,Sapna Pradyuman Patel,Scott E. Woodman,Rodabe N. Amaria,Michael A. Davies,Jeffrey E. Gershenwald,Patrick Hwu,J. E. Lee,Jianhua Zhang,Lisa M. Coussens,Zachary A. Cooper,P.A. Futreal,Carrie R. Daniel,Carrie R. Daniel,Nadim J. Ajami,Joseph F. Petrosino,Michael T. Tetzlaff,Pradeep Sharma,James P. Allison,Robert R. Jenq,Jennifer A. Wargo +71 more
TL;DR: Examination of the oral and gut microbiome of melanoma patients undergoing anti-programmed cell death 1 protein (PD-1) immunotherapy suggested enhanced systemic and antitumor immunity in responding patients with a favorable gut microbiome as well as in germ-free mice receiving fecal transplants from responding patients.
Journal ArticleDOI
Dietary inflammatory potential in relation to the gut microbiome: results from a cross-sectional study
Jiali Zheng,K. Hoffman,K. Hoffman,Jiun Sheng Chen,Nitin Shivappa,Akhil Sood,Akhil Sood,Gladys Browman,Danika D. Dirba,Samir M. Hanash,Peng Wei,James R. Hebert,Joseph F. Petrosino,Susan M. Schembre,Susan M. Schembre,Carrie R. Daniel +15 more
TL;DR: An index reflecting overall inflammatory potential of the diet was associated with specific microbes, but not overall diversity of the gut microbiome in the study, warranting further research in larger samples and prospective cohorts.
Journal ArticleDOI
Oral microbiota reveals signs of acculturation in Mexican American women.
K. Hoffman,Diane S. Hutchinson,Jerry Fowler,Daniel P. Smith,Nadim J. Ajami,Hua Zhao,Paul Scheet,Wong Ho Chow,Joseph F. Petrosino,Carrie R. Daniel +9 more
TL;DR: Describing the 16S rDNA oral microbiome in 369 non-smoking women enrolled in the MD Anderson Mano a Mano Mexican American Cohort Study suggested immigration and adaption to life in the US, a well-established mediator of disease risk, is associated with differences in oral microbial profiles in Mexican American women.
Journal ArticleDOI
Association of diversity and composition of the gut microbiome with differential responses to PD-1 based therapy in patients with metastatic melanoma.
Vancheswaran Gopalakrishnan,Christine N. Spencer,Alexandre Reuben,Tatiana Karpinets,Diane S. Hutchinson,K. Hoffman,Peter A. Prieto,Michael T. Tetzlaff,Alexander J. Lazar,Michael A. Davies,Jeffrey E. Gershenwald,Robert R. Jenq,Patrick Hwu,Padmanee Sharma,James P. Allison,Andrew Futreal,Nadim J. Ajami,Joseph F. Petrosino,Carrie Daniel-MacDougall,Jennifer A. Wargo +19 more
TL;DR: This data indicates that a second line of treatment with a second checkpoint blockade regains the ability to reprogram the immune system to attack tumours other than the T-cells involved in cell death.