T
Tatiana Karpinets
Researcher at University of Texas MD Anderson Cancer Center
Publications - 68
Citations - 6109
Tatiana Karpinets is an academic researcher from University of Texas MD Anderson Cancer Center. The author has contributed to research in topics: Cancer & Medicine. The author has an hindex of 19, co-authored 54 publications receiving 4282 citations. Previous affiliations of Tatiana Karpinets include Oak Ridge National Laboratory & University of Texas at Austin.
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Journal ArticleDOI
Gut microbiome modulates response to anti–PD-1 immunotherapy in melanoma patients
Vancheswaran Gopalakrishnan,Vancheswaran Gopalakrishnan,Christine N. Spencer,Christine N. Spencer,Luigi Nezi,Alexandre Reuben,Miles C. Andrews,Tatiana Karpinets,Peter A. Prieto,D. Vicente,K. Hoffman,Spencer C. Wei,Alexandria P. Cogdill,Li Zhao,Courtney W. Hudgens,Diane S. Hutchinson,T. Manzo,M. Petaccia de Macedo,Tiziana Cotechini,T. Kumar,Wei Shen Chen,Sangeetha M. Reddy,R. Szczepaniak Sloane,Jessica Galloway-Peña,Hong Jiang,P. L. Chen,Elizabeth J. Shpall,Katayoun Rezvani,Amin M. Alousi,Roy F. Chemaly,Samuel A. Shelburne,Luis M Vence,Pablo C. Okhuysen,V. B. Jensen,Alton G. Swennes,Florencia McAllister,E. Marcelo Riquelme Sanchez,Yu Zhang,Laurence Zitvogel,Nicolas Pons,Jacob Austin-Breneman,Lauren E. Haydu,Elizabeth M. Burton,J. M. Gardner,E. Sirmans,Jing Shan Hu,Alexander J. Lazar,Takahiro Tsujikawa,Adi Diab,Hussein Abdul-Hassan Tawbi,Isabella C. Glitza,Wen-Jen Hwu,Sapna Pradyuman Patel,Scott E. Woodman,Rodabe N. Amaria,Michael A. Davies,Jeffrey E. Gershenwald,Patrick Hwu,J. E. Lee,Jianhua Zhang,Lisa M. Coussens,Zachary A. Cooper,P.A. Futreal,Carrie R. Daniel,Carrie R. Daniel,Nadim J. Ajami,Joseph F. Petrosino,Michael T. Tetzlaff,Pradeep Sharma,James P. Allison,Robert R. Jenq,Jennifer A. Wargo +71 more
TL;DR: Examination of the oral and gut microbiome of melanoma patients undergoing anti-programmed cell death 1 protein (PD-1) immunotherapy suggested enhanced systemic and antitumor immunity in responding patients with a favorable gut microbiome as well as in germ-free mice receiving fecal transplants from responding patients.
Journal ArticleDOI
Insights from 20 years of bacterial genome sequencing
Miriam Land,Loren Hauser,Se-Ran Jun,Intawat Nookaew,Michael R. Leuze,Tae-Hyuk Ahn,Tatiana Karpinets,Ole Lund,Guruprased H. Kora,Trudy M. Wassenaar,Suresh Poudel,David W. Ussery +11 more
TL;DR: A series of questions are explored to highlight some insights that comparative genomics has produced and how it could revolutionize medicine in terms of speed and accuracy of finding pathogens and knowing how to treat them.
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Distinct Microbial Communities within the Endosphere and Rhizosphere of Populus deltoides Roots across Contrasting Soil Types
Neil Gottel,Hector F. Castro,Hector F. Castro,Marilyn K. Kerley,Zamin Yang,Dale A. Pelletier,Mircea Podar,Mircea Podar,Tatiana Karpinets,Tatiana Karpinets,Ed Uberbacher,Gerald A. Tuskan,Gerald A. Tuskan,Rytas Vilgalys,Mitchel J. Doktycz,Christopher W. Schadt,Christopher W. Schadt +16 more
TL;DR: Analysis of microbial communities from the root endophytic and rhizospheric habitats of Populus deltoides in mature natural trees from both upland and bottomland sites in central Tennessee demonstrates that root endophical communities are distinct assemblages rather than opportunistic subsets of the rhizosphere.
Journal ArticleDOI
Increased Tumor Glycolysis Characterizes Immune Resistance to Adoptive T Cell Therapy.
Tina Cascone,Jodi A. McKenzie,Rina M. Mbofung,Simone Punt,Zhe Wang,Chunyu Xu,Leila Williams,Zhiqiang Wang,Christopher A. Bristow,Alessandro Carugo,Michael Peoples,Lerong Li,Tatiana Karpinets,Lu Huang,Shruti Malu,Caitlin Creasy,Sara E. Leahey E. Leahey,Jiong Chen,Yuan Chen,Helen Pelicano,Chantale Bernatchez,Y.N. Vashisht Gopal,Timothy P. Heffernan,Jianhua Hu,Jing Wang,Rodabe N. Amaria,Levi A. Garraway,Peng Huang,Peiying Yang,Ignacio I. Wistuba,Scott E. Woodman,Jason Roszik,R. Eric Davis,Michael A. Davies,John V. Heymach,Patrick Hwu,Weiyi Peng +36 more
TL;DR: It is demonstrated that tumor glycolysis is associated with the efficacy of ACT and the glycolynsis pathway is identified as a candidate target for combinatorial therapeutic intervention.
Journal ArticleDOI
CAZymes Analysis Toolkit (CAT): Web service for searching and analyzing carbohydrate-active enzymes in a newly sequenced organism using CAZy database
Byung H. Park,Tatiana Karpinets,Tatiana Karpinets,Mustafa H Syed,Michael R. Leuze,Edward C. Uberbacher +5 more
TL;DR: The proposed framework to predict the function of unknown protein domains and of hypothetical proteins in the genome of Neurospora crassa is demonstrated and is implemented as a Web service, the CAZymes Analysis Toolkit, and is available at http://cricket.ornl.gov/cgi-bin/cat.cgi