K
K.K. Hallenbeck
Researcher at University of California, San Francisco
Publications - 8
Citations - 269
K.K. Hallenbeck is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Mass spectrometry & Liquid chromatography–mass spectrometry. The author has an hindex of 4, co-authored 6 publications receiving 166 citations. Previous affiliations of K.K. Hallenbeck include University of California, Berkeley.
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Journal ArticleDOI
Fibrin-targeting immunotherapy protects against neuroinflammation and neurodegeneration.
Jae K. Ryu,Victoria A. Rafalski,Anke Meyer-Franke,Ryan A. Adams,Suresh Poda,Pamela E. Rios Coronado,Lars Østergaard Pedersen,Veena Menon,Kim M. Baeten,Shoana L. Sikorski,Catherine Bedard,Kristina Hanspers,Sophia Bardehle,Andrew S. Mendiola,Dimitrios Davalos,Dimitrios Davalos,Michael R. Machado,Justin P. Chan,Ioanna Plastira,Ioanna Plastira,Mark A. Petersen,Mark A. Petersen,Samuel J. Pfaff,Kenny K. H. Ang,K.K. Hallenbeck,Catriona Syme,Hiroyuki Hakozaki,Mark H. Ellisman,Raymond A. Swanson,Raymond A. Swanson,Scott S. Zamvil,Michelle R. Arkin,Stevin H. Zorn,Alexander R. Pico,Lennart Mucke,Lennart Mucke,Stephen B. Freedman,Jeffrey B. Stavenhagen,Robert B. Nelson,Katerina Akassoglou,Katerina Akassoglou,Katerina Akassoglou +41 more
TL;DR: Fibrin-targeting immunotherapy inhibited autoimmunity- and amyloid-driven neurotoxicity and might have clinical benefit without globally suppressing innate immunity or interfering with coagulation in diverse neurological diseases.
Journal ArticleDOI
Site-Directed Fragment-Based Screening for the Discovery of Protein-Protein Interaction Stabilizers.
Eline Sijbesma,K.K. Hallenbeck,Seppe Leysen,P.J. de Vink,Lukasz Skora,Wolfgang Jahnke,Luc Brunsveld,Michelle R. Arkin,Christian Ottmann +8 more
TL;DR: This first of its kind study illustrates the potential of the tethering approach to overcome the hurdles in systematic PPI stabilizer discovery by identifying orthosteric stabilizers that increase 14-3-3/ERα affinity up to 40-fold and proposing the mechanism of stabilization based on X-ray crystal structures.
Journal ArticleDOI
Targeting Non-Catalytic Cysteine Residues Through Structure-Guided Drug Discovery.
TL;DR: Three applications of cysteinemodifying small molecules are reviewed: the optimization of existing drug leads, the discovery of new lead compounds, and the use of cysteine-reactive molecules as probes of protein dynamics.
Journal ArticleDOI
A Liquid Chromatography/Mass Spectrometry Method for Screening Disulfide Tethering Fragments:
K.K. Hallenbeck,Julia Davies,Connie Merron,Pierce Ogden,Eline Sijbesma,Christian Ottmann,Adam R. Renslo,Christopher G. Wilson,Michelle R. Arkin +8 more
TL;DR: The refinement of a high-throughput, liquid chromatography/mass spectrometry (LC/MS)–based screening method for the identification of covalent small-molecule binders to proteins, which is applicable to protein targets of various classes and a range of molecular masses is reported.
Journal ArticleDOI
Exploration of a 14-3-3 PPI Pocket by Covalent Fragments as Stabilizers.
Eline Sijbesma,K.K. Hallenbeck,Sebastian A. Andrei,Reanne R. Rust,Joris M. C. Adriaans,Luc Brunsveld,Michelle R. Arkin,Christian Ottmann +7 more
TL;DR: In this article, the authors provide an assessment of the composite PPI target pocket and the molecular characteristics of various fragments binding to a specific subpocket, highlighting the basic principles for PPI stabilization by these covalent fragments.