P
Philip R. Johnson
Researcher at Children's Hospital of Philadelphia
Publications - 111
Citations - 9418
Philip R. Johnson is an academic researcher from Children's Hospital of Philadelphia. The author has contributed to research in topics: Simian immunodeficiency virus & Virus. The author has an hindex of 47, co-authored 110 publications receiving 9084 citations. Previous affiliations of Philip R. Johnson include University of Pennsylvania & National Institutes of Health.
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An African primate lentivirus (SIVsm) closely related to HIV-2
Vanessa M. Hirsch,Robert A. Olmsted,Michael Murphey-Corb,Robert H. Purcell,Philip R. Johnson +4 more
TL;DR: SIVsm has infected macaques in captivity and humans in West Africa and evolved as SIVmac and HIV-2, respectively, according to molecularly cloned and sequenced SIVsm.
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The G glycoprotein of human respiratory syncytial viruses of subgroups A and B: extensive sequence divergence between antigenically related proteins
TL;DR: The proposed extracellular domains of the G proteins contained a single region of highly conserved sequence and secondary structure that may represent a conserved structural or function domain, perhaps involved in attachment to cellular receptors, and may significantly contribute to the fact that the RSV G proteins maintain significant antigenic relatedness.
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Proof of principle for epitope-focused vaccine design
Bruno E. Correia,John T. Bates,Rebecca J. Loomis,Gretchen Baneyx,Chris Carrico,Joseph G. Jardine,Peter B. Rupert,Colin Correnti,Oleksandr Kalyuzhniy,Vinayak Vittal,Mary J. Connell,Eric Stevens,Alexandria Schroeter,Man Chen,Skye MacPherson,Andreia M. Serra,Yumiko Adachi,Margaret A. Holmes,Yuxing Li,Rachel E. Klevit,Barney S. Graham,Richard T. Wyatt,David Baker,Roland K. Strong,James E. Crowe,Philip R. Johnson,William R. Schief +26 more
TL;DR: In this paper, computational protein design can generate small, thermally and conformationally stable protein scaffolds that accurately mimic the viral epitope structure and induce potent neutralizing antibodies.
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Expression of the F glycoprotein of respiratory syncytial virus by a recombinant vaccinia virus: comparison of the individual contributions of the F and G glycoproteins to host immunity
Robert A. Olmsted,Narayanasamy Elango,Gregory A. Prince,Brian R. Murphy,Philip R. Johnson,Bernard Moss,Robert M. Chanock,Peter L. Collins +7 more
TL;DR: A cDNA clone representing the mRNA coding sequence of the fusion glycoprotein (F) gene of human respiratory syncytial virus was constructed and inserted into the thymidine kinase gene of vaccinia virus (WR strain) under the control of a vaccine promoter.
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Vector-mediated gene transfer engenders long-lived neutralizing activity and protection against SIV infection in monkeys.
Philip R. Johnson,Bruce C. Schnepp,Jianchao Zhang,Mary J. Connell,Sean M Greene,Eloísa Yuste,Ronald C. Desrosiers,K. Reed Clark +7 more
TL;DR: Using the simian immunodeficiency virus (SIV) model, long-lasting neutralizing activity in serum is generated and monkeys are observed to have complete protection against intravenous challenge with virulent SIV.