Kadi Lõhmussaar

TL;DR: A biobank of ovarian cancer organoids recapitulates the histopathological and molecular hallmarks of patient tumors and provides a resource for preclinical research and demonstrates their potential application for research and personalized medicine.

TL;DR: Conditions for long-term culture of human mucosal organoids derived from head and neck squamous cell carcinoma (HNSCC) are described and responses to therapies both currently used in the treatment of HNSCC and those not used in clinical practice are observed.

TL;DR: Evaluating the capacity of patient-derived organoids (PDOs) to predict clinical drug response and functional consequences of tumor heterogeneity finds that generating PDOs of multiple tumor locations can improve clinical decision making and increase the knowledge of genetic and drug response heterogeneity.

TL;DR: The results support the dual origin hypothesis of HG-SOC, as it is demonstrated that both epithelia can give rise to ovarian tumors with high-grade pathology, however, the mutated oviductal organoids expand much faster in vitro and more readily form malignant tumors upon transplantation.

TL;DR: In this paper, a long-term culturing protocol for ecto-and endocervical epithelia was described that generates 3D organoids that stably recapitulate the two tissues of origin.