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Kaitlyn Tkachuk
Researcher at Memorial Sloan Kettering Cancer Center
Publications - 17
Citations - 406
Kaitlyn Tkachuk is an academic researcher from Memorial Sloan Kettering Cancer Center. The author has contributed to research in topics: Medicine & Germline. The author has an hindex of 5, co-authored 12 publications receiving 104 citations.
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Journal ArticleDOI
Mismatch Repair-Deficient Rectal Cancer and Resistance to Neoadjuvant Chemotherapy.
Andrea Cercek,Gustavo Dos Santos Fernandes,Campbell S.D. Roxburgh,Karuna Ganesh,S.Y. Ng,Francisco Sanchez-Vega,Rona Yaeger,Neil H. Segal,Diane Reidy-Lagunes,Anna M. Varghese,Arnold J. Markowitz,Chao Wu,Bryan C. Szeglin,Charles-Etienne Gabriel Sauve,Erin E. Salo-Mullen,Christina Tran,Zalak Patel,Asha Krishnan,Kaitlyn Tkachuk,Garrett M. Nash,Jose G. Guillem,Philip B. Paty,Jinru Shia,Nikolaus Schultz,Julio Garcia-Aguilar,Luis A. Diaz,Karyn A. Goodman,Leonard B. Saltz,Martin R. Weiser,J. Joshua Smith,Zsofia K. Stadler +30 more
Abstract: Purpose: Evaluate response of mismatch repair–deficient (dMMR) rectal cancer to neoadjuvant chemotherapy. Experimental Design: dMMR rectal tumors at Memorial Sloan Kettering Cancer Center (New York, NY) were retrospectively reviewed for characteristics, treatment, and outcomes. Fifty patients with dMMR rectal cancer were identified by IHC and/or microsatellite instability analysis, with initial treatment response compared with a matched MMR-proficient (pMMR) rectal cancer cohort. Germline and somatic mutation analyses were evaluated. Patient-derived dMMR rectal tumoroids were assessed for chemotherapy sensitivity. Results: Of 21 patients receiving neoadjuvant chemotherapy (fluorouracil/oxaliplatin), six (29%) had progression of disease. In comparison, no progression was noted in 63 pMMR rectal tumors (P = 0.0001). Rectal cancer dMMR tumoroids reflected this resistance to chemotherapy. No genomic predictors of chemotherapy response were identified. Of 16 patients receiving chemoradiation, 13 (93%) experienced tumor downstaging; one patient had stable disease, comparable with 48 pMMR rectal cancers. Of 13 patients undergoing surgery, 12 (92%) had early-stage disease. Forty-two (84%) of the 50 patients tested positive for Lynch syndrome with enrichment of germline MSH2 and MSH6 mutations when compared with 193 patients with Lynch syndrome–associated colon cancer (MSH2, 57% vs 36%; MSH6, 17% vs 9%; P Conclusions: Over one-fourth of dMMR rectal tumors treated with neoadjuvant chemotherapy exhibited disease progression. Conversely, dMMR rectal tumors were sensitive to chemoradiation. MMR status should be performed upfront in all locally advanced rectal tumors with careful monitoring for response on neoadjuvant chemotherapy and genetic testing for Lynch syndrome in patients with dMMR rectal cancer.
Journal ArticleDOI
Therapeutic Implications of Germline Testing in Patients With Advanced Cancers.
Zsofia K. Stadler,Anna Maio,Debyani Chakravarty,Yelena Kemel,Margaret Sheehan,Erin E. Salo-Mullen,Kaitlyn Tkachuk,Christopher J. Fong,Bastien Nguyen,Amanda Erakky,Karen Cadoo,Ying Liu,Maria I. Carlo,Alicia Latham,Hongxin Zhang,Ritika Kundra,Shaleigh A. Smith,Jesse Galle,Carol Aghajanian,Nadeem R. Abu-Rustum,Anna M. Varghese,Eileen M. O'Reilly,Michael J. Morris,Wassim Abida,Michael Walsh,Alexander Drilon,Gowtham Jayakumaran,Ahmet Zehir,Marc Ladanyi,Ozge Ceyhan-Birsoy,David B. Solit,Nikolaus Schultz,Michael F. Berger,Diana Mandelker,Luis A. Diaz,Kenneth Offit,Mark E. Robson +36 more
TL;DR: In this paper, the extent to which mutation profiling guides therapy selection in patients with advanced cancer was determined, and it was shown that mutation profiling is increasingly performed in patients who have advanced cancer.
Journal ArticleDOI
Cancer Susceptibility Mutations in Patients With Urothelial Malignancies
Maria I. Carlo,Vignesh Ravichandran,Preethi Srinavasan,Chaitanya Bandlamudi,Yelena Kemel,Ozge Ceyhan-Birsoy,Semanti Mukherjee,Diana Mandelker,Joshua Chaim,Andrea Knezevic,Satshil Rana,Zarina Fnu,Kelsey Breen,Angela G. Arnold,Aliya Khurram,Kaitlyn Tkachuk,Catharine Kline Cipolla,Ashley Marie Regazzi,A. Ari Hakimi,Hikmat Al-Ahmadie,Guido Dalbagni,Karen Cadoo,Michael Walsh,Min Yuen Teo,Samuel Funt,Jonathan A. Coleman,Bernard H. Bochner,Gopa Iyer,David B. Solit,Zsofia K. Stadler,Liying Zhang,Jonathan E. Rosenberg,Barry S. Taylor,Mark E. Robson,Michael F. Berger,Joseph Vijai,Dean F. Bajorin,Kenneth Offit +37 more
TL;DR: Clinically significant P/LP germline variants in DNA-damage repair (DDR) genes frequently are present in patients with advanced UC and could guide cancer screening for patients and their families and serve as predictive biomarkers of response to targeted or immunotherapies.
Journal ArticleDOI
Clonal hematopoiesis is associated with risk of severe Covid-19.
Kelly L. Bolton,Youngil Koh,Michael B. Foote,Hogune Im,Justin Jee,Choong Hyun Sun,Anton Safonov,Ryan Ptashkin,Joon Ho Moon,Ji Yeon Lee,Jongtak Jung,Chang Kyung Kang,Kyoung Ho Song,Pyoeng Gyun Choe,Wan Beom Park,Hong Bin Kim,Myoung Don Oh,Han Song,Sugyeong Kim,Minal Patel,Andriy Derkach,Erika Gedvilaite,Kaitlyn Tkachuk,Brian J. Wiley,Ireaneus C. Chan,Lior Z. Braunstein,Teng Gao,Elli Papaemmanuil,N. Esther Babady,Melissa S. Pessin,Mini Kamboj,Luis A. Diaz,Marc Ladanyi,Michael J. Rauh,Pradeep Natarajan,Pradeep Natarajan,Mitchell J. Machiela,Philip Awadalla,Vijai Joseph,Kenneth Offit,Larry Norton,Michael F. Berger,Ross L. Levine,Eu Suk Kim,Nam Joong Kim,Ahmet Zehir +45 more
TL;DR: In this paper, the authors show that acquired somatic mutations in hematopoietic stem and progenitor cells are associated with advanced age, increased risk of cardiovascular and malignant diseases, and decreased overall survival.
Journal ArticleDOI
Cascading After Peridiagnostic Cancer Genetic Testing: An Alternative to Population-Based Screening
Kenneth Offit,Kenneth Offit,Kaitlyn Tkachuk,Zsofia K. Stadler,Zsofia K. Stadler,Michael Walsh,Hector Diaz-Zabala,Jeffrey Levin,Zoe Steinsnyder,Vignesh Ravichandran,Ravi Sharaf,Melissa K. Frey,Steven M. Lipkin,Mark E. Robson,Mark E. Robson,Jada G. Hamilton,Jada G. Hamilton,Joseph Vijai,Joseph Vijai,Semanti Mukherjee +19 more
TL;DR: Peridiagnostic and cascade cancer genetic testing offers an alternative strategy to achieve population-wide identification of cancer susceptibility mutations.