K
Kaori Nakayama-Hosoya
Researcher at University of Tokyo
Publications - 4
Citations - 364
Kaori Nakayama-Hosoya is an academic researcher from University of Tokyo. The author has contributed to research in topics: Medicine & Induced pluripotent stem cell. The author has an hindex of 2, co-authored 2 publications receiving 306 citations.
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Journal ArticleDOI
Generation of Rejuvenated Antigen-Specific T Cells by Reprogramming to Pluripotency and Redifferentiation
Toshinobu Nishimura,Shin Kaneko,Ai Kawana-Tachikawa,Yoko Tajima,Haruo Goto,Dayong Zhu,Kaori Nakayama-Hosoya,Shoichi Iriguchi,Yasushi Uemura,Takafumi Shimizu,Naoya Takayama,Daisuke Yamada,Ken Nishimura,Manami Ohtaka,Nobukazu Watanabe,Satoshi Takahashi,Aikichi Iwamoto,Haruhiko Koseki,Mahito Nakanishi,Koji Eto,Hiromitsu Nakauchi +20 more
TL;DR: This work reprogrammed clonally expanded antigen-specific CD8(+) T cells from an HIV-1-infected patient to pluripotency and found that this method can be effective for generating specific T-cells for other pathology-associated antigens.
Journal ArticleDOI
Epigenetic Repression of Interleukin 2 Expression in Senescent CD4+ T Cells During Chronic HIV Type 1 Infection
Kaori Nakayama-Hosoya,Takaomi Ishida,Ben Youngblood,Hitomi Nakamura,Noriaki Hosoya,Michiko Koga,Tomohiko Koibuchi,Aikichi Iwamoto,Ai Kawana-Tachikawa +8 more
TL;DR: Data suggest that DNA methylation at the IL2 locus in CD4(+) T cells is coupled to immunosenescence and plays a critical role in the broad dysfunction that occurs in polyclonal T cells during HIV-1 infection.
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Sustainable Antiviral Efficacy of Rejuvenated HIV-Specific Cytotoxic T Lymphocytes Generated from Induced Pluripotent Stem Cells
Shoji Miki,Yohei Kawai,Kaori Nakayama-Hosoya,Ryutaro Iwabuchi,Kazutaka Terahara,Yasuko Tsunetsugu-Yokota,Michiko Koga,Tetsuro Matano,Shin Kaneko,Ai Kawana-Tachikawa +9 more
TL;DR: The results indicate that HIV-specific iPSC-CTL can sustainably exert suppressive pressure on viral replication, suggesting a novel approach to facilitate clearance of the HIV reservoir via adoptive transfer of rejuvenated CTLs.
Journal ArticleDOI
Breadth and Durability of SARS-CoV-2-Specific T Cell Responses following Long-Term Recovery from COVID-19
Thi Thao Trang Dang,Alit Anzurez,Kaori Nakayama-Hosoya,Shoji Miki,Kazuo Yamashita,Mark de Souza,Tetsuro Matano,Ai Kawana-Tachikawa +7 more
TL;DR: In this paper , the breadth and magnitude of SARS-CoV-2-specific T cell responses were determined in COVID-19-convalescent individuals in Japan, and those with more severe disease exhibited a broader T cell response relative to cases with mild symptoms.