Y
Yoko Tajima
Researcher at University of Tokyo
Publications - 13
Citations - 1038
Yoko Tajima is an academic researcher from University of Tokyo. The author has contributed to research in topics: Haematopoiesis & Stem cell. The author has an hindex of 10, co-authored 13 publications receiving 884 citations.
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Journal ArticleDOI
Generation of Rejuvenated Antigen-Specific T Cells by Reprogramming to Pluripotency and Redifferentiation
Toshinobu Nishimura,Shin Kaneko,Ai Kawana-Tachikawa,Yoko Tajima,Haruo Goto,Dayong Zhu,Kaori Nakayama-Hosoya,Shoichi Iriguchi,Yasushi Uemura,Takafumi Shimizu,Naoya Takayama,Daisuke Yamada,Ken Nishimura,Manami Ohtaka,Nobukazu Watanabe,Satoshi Takahashi,Aikichi Iwamoto,Haruhiko Koseki,Mahito Nakanishi,Koji Eto,Hiromitsu Nakauchi +20 more
TL;DR: This work reprogrammed clonally expanded antigen-specific CD8(+) T cells from an HIV-1-infected patient to pluripotency and found that this method can be effective for generating specific T-cells for other pathology-associated antigens.
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Identification and characterization of a novel lysophosphatidic acid receptor, p2y5/LPA6.
Keisuke Yanagida,Kayo Masago,Hiroki Nakanishi,Yasuyuki Kihara,Fumie Hamano,Yoko Tajima,Ryo Taguchi,Takao Shimizu,Satoshi Ishii +8 more
TL;DR: It is reported that p2y5 is a novel LPA receptor coupling to the G13-Rho signaling pathway and proposed to designate this receptor LPA6.
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Plasma and serum lipidomics of healthy white adults shows characteristic profiles by subjects' gender and age.
Masaki Ishikawa,Keiko Maekawa,Kosuke Saito,Yuya Senoo,Masayo Urata,Mayumi Murayama,Yoko Tajima,Yuji Kumagai,Yoshiro Saito +8 more
TL;DR: Results indicate that plasma is an optimal matrix for exploring lipid biomarkers because it represents the original properties of an individual’s blood sample and age- and gender-associated differences were more prominent in females than in males.
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Lipidomic analysis of brain tissues and plasma in a mouse model expressing mutated human amyloid precursor protein/tau for Alzheimer’s disease
Yoko Tajima,Masaki Ishikawa,Keiko Maekawa,Mayumi Murayama,Yuya Senoo,Tomoko Nishimaki-Mogami,Hiroki Nakanishi,Kazutaka Ikeda,Makoto Arita,Ryo Taguchi,Alato Okuno,Ryuta Mikawa,Shumpei Niida,Osamu Takikawa,Yoshiro Saito +14 more
TL;DR: The results provide fundamental information on lipid dysregulation during various stages of human AD and indicate a perturbation of membrane properties.
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Global metabolomic analysis of heart tissue in a hamster model for dilated cardiomyopathy
Keiko Maekawa,Akiyoshi Hirayama,Yuko Iwata,Yoko Tajima,Tomoko Nishimaki-Mogami,Shoko Sugawara,Noriko Ueno,Hiroshi Abe,Masaki Ishikawa,Mayumi Murayama,Y. Matsuzawa,Hiroki Nakanishi,Kazutaka Ikeda,Makoto Arita,Ryo Taguchi,Naoto Minamino,Shigeo Wakabayashi,Tomoyoshi Soga,Yoshiro Saito +18 more
TL;DR: Global metabolomic analysis of myocardial tissues from the left ventricles of J2N-k cardiomyopathic hamsters provides mechanistic insights into DCM pathogenesis and may help identify new targets for therapeutic intervention and diagnosis.