Generation of Rejuvenated Antigen-Specific T Cells by Reprogramming to Pluripotency and Redifferentiation
Toshinobu Nishimura,Shin Kaneko,Ai Kawana-Tachikawa,Yoko Tajima,Haruo Goto,Dayong Zhu,Kaori Nakayama-Hosoya,Shoichi Iriguchi,Yasushi Uemura,Takafumi Shimizu,Naoya Takayama,Daisuke Yamada,Ken Nishimura,Manami Ohtaka,Nobukazu Watanabe,Satoshi Takahashi,Aikichi Iwamoto,Haruhiko Koseki,Mahito Nakanishi,Koji Eto,Hiromitsu Nakauchi +20 more
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TLDR
This work reprogrammed clonally expanded antigen-specific CD8(+) T cells from an HIV-1-infected patient to pluripotency and found that this method can be effective for generating specific T-cells for other pathology-associated antigens.About:
This article is published in Cell Stem Cell.The article was published on 2013-01-03 and is currently open access. It has received 325 citations till now. The article focuses on the topics: CD8 & Induced pluripotent stem cell.read more
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Molecular and cellular insights into T cell exhaustion
E. John Wherry,Makoto Kurachi +1 more
TL;DR: Recent advances that provide a clearer molecular understanding of T cell exhaustion are reviewed and reveal new therapeutic targets for persisting infections and cancer.
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Therapeutic T cell engineering
TL;DR: Engineered T cells are applicable in principle to many cancers, pending further progress to identify suitable target antigens, overcome immunosuppressive tumour microenvironments, reduce toxicities, and prevent antigen escape.
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Generation of tumor-targeted human T lymphocytes from induced pluripotent stem cells for cancer therapy
Maria Themeli,Christopher C. Kloss,Giovanni Ciriello,Victor D. Fedorov,Fabiana Perna,Mithat Gonen,Michel Sadelain +6 more
TL;DR: In this paper, the authors combine induced pluripotent stem cells (iPSC) and chimeric antigen receptor (CAR) technologies to generate human T cells targeted to CD19, an antigen expressed by malignant B cells, in tissue culture.
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iPS cells: a game changer for future medicine
TL;DR: The induced pluripotent stem cell (iPSC) technology is instrumental in advancing the fields of disease modeling and cell transplantation, and their use would tightly connect both micro‐ and macromedicine for drug discovery and clinical trials.
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Treg cell-based therapies: challenges and perspectives.
TL;DR: The biology of Treg cells is discussed and new efforts in Treg cell engineering to enhance specificity, stability, functional activity and delivery are described to encourage the clinical use of adoptive TReg cell therapy for non-immune diseases, such as neurological disorders and tissue repair.
References
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Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors
Kazutoshi Takahashi,Koji Tanabe,Mari Ohnuki,Megumi Narita,Tomoko Ichisaka,Kiichiro Tomoda,Shinya Yamanaka +6 more
TL;DR: It is demonstrated that iPS cells can be generated from adult human fibroblasts with the same four factors: Oct3/4, Sox2, Klf4, and c-Myc.
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Induction of Pluripotent Stem Cells From Adult Human Fibroblasts by Defined Factors
Kazutoshi Takahashi,Koji Tanabe,Mari Ohnuki,Megumi Narita,Tomoko Ichisaka,Kiichiro Tomoda,Shinya Yamanaka +6 more
TL;DR: This work generated induced pluripotent stem cells capable of germline transmission from murine somatic cells by transd, and demonstrated the ability of these cells to reprogram into patient-specific and disease-specific stem cells.
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Chimeric Antigen Receptor–Modified T Cells in Chronic Lymphoid Leukemia
TL;DR: A low dose of autologous chimeric antigen receptor-modified T cells reinfused into a patient with refractory chronic lymphocytic leukemia expanded to a level that was more than 1000 times as high as the initial engraftment level in vivo, with delayed development of the tumor lysis syndrome and with complete remission.
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Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors
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T cell exhaustion
TL;DR: Advances in the molecular delineation of T cell exhaustion are clarifying the underlying causes of this state of differentiation and also suggest promising therapeutic opportunities.