Showing papers by "Kara Dolinski published in 2008"
TL;DR: The GO Consortium has launched a focused effort to provide comprehensive and detailed annotation of orthologous genes across a number of ‘reference’ genomes, including human and several key model organisms.
Abstract: The Gene Ontology (GO) project (http://www.geneontology.org) provides a set of structured, controlled vocabularies for community use in annotating genes, gene products and sequences (also see http://www.sequenceontology.org/). The ontologies have been extended and refined for several biological areas, and improvements to the structure of the ontologies have been implemented. To improve the quantity and quality of gene product annotations available from its public repository, the GO Consortium has launched a focused effort to provide comprehensive and detailed annotation of orthologous genes across a number of reference genomes, including human and several key model organisms. Software developments include two releases of the ontology-editing tool OBO-Edit, and improvements to the AmiGO browser interface.
726 citations
TL;DR: Key aspects of GO are described, which, when overlooked, can cause erroneous results, and how these pitfalls can be avoided.
Abstract: The Gene Ontology (GO) project is a collaboration among model organism databases to describe gene products from all organisms using a consistent and computable language. GO produces sets of explicitly defined, structured vocabularies that describe biological processes, molecular functions and cellular components of gene products in both a computer- and human-readable manner. Here we describe key aspects of GO, which, when overlooked, can cause erroneous results, and address how these pitfalls can be avoided.
508 citations
01 Jan 2008
TL;DR: The next generation of policymakers and decision-makers will have to consider climate change in a more holistic way than in the past, and how to respond to it in a socially responsible way.
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2 citations