K
Kara L. Davis
Researcher at Stanford University
Publications - 98
Citations - 9648
Kara L. Davis is an academic researcher from Stanford University. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 20, co-authored 66 publications receiving 6382 citations. Previous affiliations of Kara L. Davis include Lucile Packard Children's Hospital & Thomas Jefferson University.
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Journal ArticleDOI
Tisagenlecleucel in Children and Young Adults with B-Cell Lymphoblastic Leukemia
Shannon L. Maude,Theodore W. Laetsch,Jochen Buechner,S. Rives,Michael Boyer,Henrique Bittencourt,Peter Bader,Michael R. Verneris,Heather E. Stefanski,G.D. Myers,Muna Qayed,B. De Moerloose,Hidefumi Hiramatsu,Krysta Schlis,Kara L. Davis,Paul L. Martin,Eneida R. Nemecek,Gregory A. Yanik,Christina Peters,André Baruchel,Nicolas Boissel,Francoise Mechinaud,Adriana Balduzzi,Joerg Krueger,Carl H. June,Bruce L. Levine,Patricia A. Wood,Tanya Taran,Mimi Leung,Karen Thudium Mueller,Yiyun Zhang,Kapildeb Sen,David Lebwohl,Michael A. Pulsipher,Stephan A. Grupp +34 more
TL;DR: In this global study of CAR T‐cell therapy, a single infusion of tisagenlecleucel provided durable remission with long‐term persistence in pediatric and young adult patients with relapsed or refractory B‐cell ALL, with transient high‐grade toxic effects.
Journal ArticleDOI
Data-Driven Phenotypic Dissection of AML Reveals Progenitor-like Cells that Correlate with Prognosis.
Jacob H. Levine,Erin F. Simonds,Sean C. Bendall,Kara L. Davis,El-ad David Amir,Michelle D. Tadmor,Oren Litvin,Harris G. Fienberg,Astraea Jager,Eli R. Zunder,Rachel Finck,Amanda Larson Gedman,Ina Radtke,James R. Downing,Dana Pe'er,Garry P. Nolan +15 more
TL;DR: Using hematopoietic progenitors, a signaling-based measure of cellular phenotype was defined, which led to isolation of a gene expression signature that was predictive of survival in independent cohorts, yielding insights into AML pathophysiology.
Journal ArticleDOI
viSNE enables visualization of high dimensional single-cell data and reveals phenotypic heterogeneity of leukemia
El-ad David Amir,Kara L. Davis,Michelle D. Tadmor,Erin F. Simonds,Jacob H. Levine,Sean C. Bendall,Daniel K. Shenfeld,Smita Krishnaswamy,Garry P. Nolan,Dana Pe'er +9 more
TL;DR: In this article, the authors present viSNE, a tool that allows one to map high-dimensional cytometry data onto two dimensions, yet conserve the highdimensional structure of the data by using all pairwise distances in high dimension to determine each cell's location in the plot.
Journal ArticleDOI
Single-Cell Trajectory Detection Uncovers Progression and Regulatory Coordination in Human B Cell Development
Sean C. Bendall,Kara L. Davis,El-ad David Amir,Michelle D. Tadmor,Erin F. Simonds,Tiffany J. Chen,Daniel K. Shenfeld,Garry P. Nolan,Dana Pe'er +8 more
TL;DR: This study provides a comprehensive analysis of human B lymphopoiesis, laying a foundation to apply this approach to other tissues and "corrupted" developmental processes including cancer.
Journal ArticleDOI
Automated mapping of phenotype space with single-cell data
TL;DR: X-shift is presented, an algorithm that processes data sets using fast k-nearest-neighbor estimation of cell event density and arranges populations by marker-based classification and enables automated cell-subset clustering and access to biological insights that 'prior knowledge' might prevent the researcher from discovering.