A
Amanda Larson Gedman
Researcher at St. Jude Children's Research Hospital
Publications - 12
Citations - 2993
Amanda Larson Gedman is an academic researcher from St. Jude Children's Research Hospital. The author has contributed to research in topics: Leukemia & Cancer. The author has an hindex of 10, co-authored 12 publications receiving 2257 citations. Previous affiliations of Amanda Larson Gedman include Wayne State University.
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Journal ArticleDOI
Data-Driven Phenotypic Dissection of AML Reveals Progenitor-like Cells that Correlate with Prognosis.
Jacob H. Levine,Erin F. Simonds,Sean C. Bendall,Kara L. Davis,El-ad David Amir,Michelle D. Tadmor,Oren Litvin,Harris G. Fienberg,Astraea Jager,Eli R. Zunder,Rachel Finck,Amanda Larson Gedman,Ina Radtke,James R. Downing,Dana Pe'er,Garry P. Nolan +15 more
TL;DR: Using hematopoietic progenitors, a signaling-based measure of cellular phenotype was defined, which led to isolation of a gene expression signature that was predictive of survival in independent cohorts, yielding insights into AML pathophysiology.
Journal ArticleDOI
The landscape of somatic mutations in infant MLL-rearranged acute lymphoblastic leukemias.
Anna Andersson,Anna Andersson,Jing Ma,Jianmin Wang,Xiang Chen,Amanda Larson Gedman,Jinjun Dang,Joy Nakitandwe,Linda Holmfeldt,Matthew Parker,John Easton,Robert Huether,Richard W. Kriwacki,Michael Rusch,Gang Wu,Yongjin Li,Heather L. Mulder,Susana C. Raimondi,Stanley Pounds,Guolian Kang,Lei Shi,Jared Becksfort,Pankaj Gupta,Debbie Payne-Turner,Bhavin Vadodaria,Kristy Boggs,Donald Yergeau,Jayanthi Manne,Guangchun Song,Michael N. Edmonson,Panduka Nagahawatte,Lei Wei,C. Cheng,Deqing Pei,Rosemary Sutton,Nicola C. Venn,Albert Chetcuti,Amanda Rush,Daniel Catchpoole,Jesper Heldrup,Thoas Fioretos,Charles Lu,Li Ding,Ching-Hon Pui,Sheila A. Shurtleff,Charles G. Mullighan,Elaine R. Mardis,Richard K. Wilson,Tanja A. Gruber,Jinghui Zhang,James R. Downing +50 more
TL;DR: Infant acute lymphoblastic leukemia (ALL) with MLL rearrangements (MLL-R) represents a distinct leukemia with a poor prognosis and has one of the lowest frequencies of somatic mutations of any sequenced cancer, with the predominant leukemic clone carrying a mean of 1.3 non-silent mutations.
Journal ArticleDOI
The landscape of somatic mutations in epigenetic regulators across 1,000 paediatric cancer genomes
Robert Huether,Li Dong,Xiang Chen,Gang Wu,Matthew Parker,Lei Wei,Jing Ma,Michael N. Edmonson,Erin Hedlund,Michael Rusch,Sheila A. Shurtleff,Heather L. Mulder,Kristy Boggs,Bhavin Vadordaria,Jinjun Cheng,Donald Yergeau,Guangchun Song,Jared Becksfort,Gordon Lemmon,Catherine Weber,Zhongling Cai,Jinjun Dang,Michael Walsh,Amanda Larson Gedman,Zachary J Faber,John Easton,Tanja A. Gruber,Richard W. Kriwacki,Janet F. Partridge,Li Ding,Richard K. Wilson,Elaine R. Mardis,Charles G. Mullighan,Richard J. Gilbertson,Suzanne J. Baker,Gerard P. Zambetti,David W. Ellison,Jinghui Zhang,James R. Downing +38 more
TL;DR: A marked variation in the frequency of gene mutations is demonstrated across 21 different paediatric cancer subtypes, with the highest frequency of mutations detected in high-grade gliomas, T-lineage acute lymphoblastic leukaemia and medulloblastoma, and a paucity of mutations in low- grade glioma and retinoblastomas.
Journal ArticleDOI
An Inv(16)(p13.3q24.3)-encoded CBFA2T3-GLIS2 fusion protein defines an aggressive subtype of pediatric acute megakaryoblastic leukemia.
Tanja A. Gruber,Amanda Larson Gedman,Jinghui Zhang,Cary Koss,Suresh Marada,Huy Q. Ta,Shann Ching Chen,Xiaoping Su,Stacey K. Ogden,Jinjun Dang,Gang Wu,Vedant Gupta,Anna Andersson,Stanley Pounds,Lei Shi,John Easton,Michael I. Barbato,Heather L. Mulder,Jayanthi Manne,Jianmin Wang,Michael Rusch,Swati Ranade,Ramapriya Ganti,Matthew Parker,Jing Ma,Ina Radtke,Li Ding,Li Ding,Giovanni Cazzaniga,Andrea Biondi,Steven M. Kornblau,Farhad Ravandi,Hagop M. Kantarjian,Stephen D. Nimer,Konstanze Döhner,Hartmut Döhner,Timothy J. Ley,Timothy J. Ley,Paola Ballerini,Sheila A. Shurtleff,Daisuke Tomizawa,Souichi Adachi,Yasuhide Hayashi,Akio Tawa,Lee Yung Shih,Der Cherng Liang,Jeffrey E. Rubnitz,Ching-Hon Pui,Elaine R. Mardis,Elaine R. Mardis,Richard K. Wilson,Richard K. Wilson,James R. Downing +52 more
TL;DR: In this article, the authors performed transcriptome sequencing on diagnostic blasts from 14 pediatric patients and validated their findings in a recurrency/validation cohort consisting of 34 pediatric and 28 adult AMKL samples.
Journal ArticleDOI
The genomic landscape of core-binding factor acute myeloid leukemias
Zachary J Faber,Xiang Chen,Amanda Larson Gedman,Kristy Boggs,Jinjun Cheng,Jing Ma,Ina Radtke,Jyh Rong Chao,Michael P. Walsh,Guangchun Song,Anna Andersson,Jinjun Dang,Li Dong,Yu Liu,Robert Huether,Zhongling Cai,Heather L. Mulder,Gang Wu,Michael N. Edmonson,Michael Rusch,Chunxu Qu,Yongjin Li,Bhavin Vadodaria,Jianmin Wang,Erin Hedlund,Xueyuan Cao,Donald Yergeau,Joy Nakitandwe,Stanley Pounds,Sheila A. Shurtleff,Robert S. Fulton,Lucinda Fulton,John Easton,Evan Parganas,Ching-Hon Pui,Jeffrey E. Rubnitz,Li Ding,Elaine R. Mardis,Richard K. Wilson,Tanja A. Gruber,Charles G. Mullighan,Richard F. Schlenk,Peter Paschka,Konstanze Döhner,Hartmut Döhner,Lars Bullinger,Jinghui Zhang,Jeffery M. Klco,James R. Downing +48 more
TL;DR: Outside of signaling alterations, RUNX1-RUNX1T1 and CBFB-MYH11 AMLs demonstrated remarkably different spectra of cooperating mutations, while highlighting dramatic differences in the landscapes of cooperate mutations for these related AML subtypes.