J
Jacob H. Levine
Researcher at Kettering University
Publications - 17
Citations - 6663
Jacob H. Levine is an academic researcher from Kettering University. The author has contributed to research in topics: T cell & Cytotoxic T cell. The author has an hindex of 13, co-authored 17 publications receiving 4958 citations. Previous affiliations of Jacob H. Levine include University of California, San Francisco & Columbia University.
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Journal ArticleDOI
Data-Driven Phenotypic Dissection of AML Reveals Progenitor-like Cells that Correlate with Prognosis.
Jacob H. Levine,Erin F. Simonds,Sean C. Bendall,Kara L. Davis,El-ad David Amir,Michelle D. Tadmor,Oren Litvin,Harris G. Fienberg,Astraea Jager,Eli R. Zunder,Rachel Finck,Amanda Larson Gedman,Ina Radtke,James R. Downing,Dana Pe'er,Garry P. Nolan +15 more
TL;DR: Using hematopoietic progenitors, a signaling-based measure of cellular phenotype was defined, which led to isolation of a gene expression signature that was predictive of survival in independent cohorts, yielding insights into AML pathophysiology.
Journal ArticleDOI
viSNE enables visualization of high dimensional single-cell data and reveals phenotypic heterogeneity of leukemia
El-ad David Amir,Kara L. Davis,Michelle D. Tadmor,Erin F. Simonds,Jacob H. Levine,Sean C. Bendall,Daniel K. Shenfeld,Smita Krishnaswamy,Garry P. Nolan,Dana Pe'er +9 more
TL;DR: In this article, the authors present viSNE, a tool that allows one to map high-dimensional cytometry data onto two dimensions, yet conserve the highdimensional structure of the data by using all pairwise distances in high dimension to determine each cell's location in the plot.
Journal ArticleDOI
Distinct Cellular Mechanisms Underlie Anti-CTLA-4 and Anti-PD-1 Checkpoint Blockade
Spencer C. Wei,Jacob H. Levine,Alexandria P. Cogdill,Yang Zhao,Nana Ama A.S. Anang,Miles C. Andrews,Padmanee Sharma,Jing Wang,Jennifer A. Wargo,Dana Pe'er,James P. Allison +10 more
TL;DR: These findings indicate that anti-CTLA-4 and anti-PD-1 checkpoint-blockade-induced immune responses are driven by distinct cellular mechanisms, and that checkpoint blockade targets only specific subsets of tumor-infiltrating T cell populations.
Journal ArticleDOI
Innate Immune Landscape in Early Lung Adenocarcinoma by Paired Single-Cell Analyses.
Yonit Lavin,Soma Kobayashi,Andrew Leader,El-ad David Amir,Naama Elefant,Camille Bigenwald,Romain Remark,Robert Sweeney,Christian Becker,Jacob H. Levine,Klaus Meinhof,Andrew Chow,Seunghee Kim-Shulze,Andrea S. Wolf,Chiara Medaglia,Hanjie Li,Julie A. Rytlewski,Ryan O. Emerson,Alexander Solovyov,Benjamin Greenbaum,Catherine Sanders,Marissa Vignali,Mary Beth Beasley,Raja M. Flores,Sacha Gnjatic,Dana Pe'er,Adeeb Rahman,Ido Amit,Miriam Merad +28 more
TL;DR: It is shown that stage I lung adenocarcinoma lesions already harbor significantly altered T cell and NK cell compartments, andaired single-cell analyses thus offer valuable knowledge of tumor-driven immune changes, providing a powerful tool for the rational design of immune therapies.
Journal ArticleDOI
An Immune Atlas of Clear Cell Renal Cell Carcinoma
Stéphane Chevrier,Jacob H. Levine,Vito R T Zanotelli,Karina Silina,Daniel Schulz,Marina Bacac,Carola Ries,Laurie Ailles,Laurie Ailles,Michael A.S. Jewett,Holger Moch,Maries van den Broek,Christian Beisel,Michael B. Stadler,Michael B. Stadler,Craig Gedye,Bernhard Reis,Dana Pe'er,Bernd Bodenmiller +18 more
TL;DR: In this paper, the authors used mass cytometry with extensive antibody panels to perform in-depth immune profiling of samples from 73 clear cell renal cell carcinoma (ccRCC) patients and five healthy controls.