M
Mehlika Hazar-Rethinam
Researcher at Harvard University
Publications - 27
Citations - 2054
Mehlika Hazar-Rethinam is an academic researcher from Harvard University. The author has contributed to research in topics: Cancer & Head and neck squamous-cell carcinoma. The author has an hindex of 17, co-authored 27 publications receiving 1442 citations. Previous affiliations of Mehlika Hazar-Rethinam include Princess Alexandra Hospital & University of Queensland.
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Journal ArticleDOI
Resistance to checkpoint blockade therapy through inactivation of antigen presentation.
Moshe Sade-Feldman,Moshe Sade-Feldman,Yunxin J. Jiao,Yunxin J. Jiao,Jonathan H. Chen,Jonathan H. Chen,Michael S. Rooney,Michal Barzily-Rokni,Jean Pierre Eliane,Stacey L. Bjorgaard,Stacey L. Bjorgaard,Marc R. Hammond,Hans Vitzthum,Shauna M. Blackmon,Dennie T. Frederick,Mehlika Hazar-Rethinam,Brandon Nadres,Emily E. Van Seventer,Sachet A. Shukla,Sachet A. Shukla,Keren Yizhak,John P. Ray,Daniel Rosebrock,Dimitri Livitz,Viktor A. Adalsteinsson,Gad Getz,Gad Getz,Lyn M. Duncan,Bo Li,Ryan B. Corcoran,Donald P. Lawrence,Anat Stemmer-Rachamimov,Genevieve M. Boland,Dan A. Landau,Dan A. Landau,Keith T. Flaherty,Ryan J. Sullivan,Nir Hacohen,Nir Hacohen +38 more
TL;DR: It is demonstrated that B2M loss is a mechanism of primary and acquired resistance to therapies targeting CTLA4 or PD-1 in melanoma patients, and is associated with poorer overall survival.
Journal ArticleDOI
Liquid versus tissue biopsy for detecting acquired resistance and tumor heterogeneity in gastrointestinal cancers.
Aparna Raj Parikh,Ignaty Leshchiner,Liudmila Elagina,Lipika Goyal,Chaya Levovitz,Giulia Siravegna,Dimitri Livitz,Kahn Rhrissorrakrai,Elizabeth E. Martin,Emily E. Van Seventer,Megan Hanna,Kara Slowik,Filippo Utro,Christopher J. Pinto,Alicia Wong,Brian P. Danysh,Ferran Fece de la Cruz,Isobel J Fetter,Brandon Nadres,Heather A. Shahzade,Jill N. Allen,Lawrence S. Blaszkowsky,Jeffrey W. Clark,Bruce J. Giantonio,Janet E. Murphy,Ryan D. Nipp,Eric Roeland,David P. Ryan,Colin D. Weekes,Eunice L. Kwak,Jason E. Faris,Jennifer Y. Wo,François Aguet,Ipsita Dey-Guha,Mehlika Hazar-Rethinam,Dora Dias-Santagata,David T. Ting,Andrew X. Zhu,Theodore S. Hong,Todd R. Golub,Todd R. Golub,Todd R. Golub,A. John Iafrate,Viktor A. Adalsteinsson,Alberto Bardelli,Laxmi Parida,Dejan Juric,Gad Getz,Ryan B. Corcoran +48 more
TL;DR: Direct prospective comparison of circulating tumor DNA and tissue biopsy sequencing shows the superiority of liquid biopsies for capturing clinically relevant alterations mediating resistance to targeted therapies in cancer patients.
Journal ArticleDOI
Real-time Genomic Characterization of Advanced Pancreatic Cancer to Enable Precision Medicine
Andrew J. Aguirre,Jonathan A. Nowak,Jonathan A. Nowak,Nicholas D. Camarda,Richard A. Moffitt,Arezou A. Ghazani,Arezou A. Ghazani,Arezou A. Ghazani,Mehlika Hazar-Rethinam,Srivatsan Raghavan,Jaegil Kim,Lauren K. Brais,Dorisanne Y. Ragon,Marisa W. Welch,Emma Reilly,Devin McCabe,Lori Marini,Lori Marini,Kristin Anderka,Karla Helvie,Karla Helvie,Nelly Oliver,Nelly Oliver,Ana Babic,Annacarolina da Silva,Annacarolina da Silva,Brandon Nadres,Emily E. Van Seventer,Heather A. Shahzade,Joseph P. St. Pierre,Kelly P. Burke,Kelly P. Burke,Thomas E. Clancy,Thomas E. Clancy,James M. Cleary,James M. Cleary,Leona A. Doyle,Leona A. Doyle,Kunal Jajoo,Kunal Jajoo,Nadine Jackson McCleary,Nadine Jackson McCleary,Jeffrey A. Meyerhardt,Jeffrey A. Meyerhardt,Janet E. Murphy,Kimmie Ng,Kimmie Ng,Anuj K. Patel,Anuj K. Patel,Kimberly Perez,Kimberly Perez,Michael H. Rosenthal,Michael H. Rosenthal,Douglas A. Rubinson,Douglas A. Rubinson,Marvin Ryou,Marvin Ryou,Geoffrey I. Shapiro,Geoffrey I. Shapiro,Ewa Sicinska,Stuart G. Silverman,Stuart G. Silverman,Rebecca J. Nagy,Richard B. Lanman,Deborah Knoerzer,Dean Welsch,Matthew B. Yurgelun,Matthew B. Yurgelun,Charles S. Fuchs,Levi A. Garraway,Gad Getz,Gad Getz,Jason L. Hornick,Jason L. Hornick,Bruce E. Johnson,Matthew H. Kulke,Matthew H. Kulke,Robert J. Mayer,Robert J. Mayer,Jeffrey W. Miller,Paul B. Shyn,Paul B. Shyn,David A. Tuveson,Nikhil Wagle,Jen Jen Yeh,William C. Hahn,Ryan B. Corcoran,Scott L. Carter,Brian M. Wolpin,Brian M. Wolpin +89 more
TL;DR: Using an integrated multidisciplinary biopsy program, it is demonstrated that real-time genomic characterization of advanced PDAC can identify clinically relevant alterations that inform management of this difficult disease.
Journal ArticleDOI
Genome sequence of an Australian kangaroo, Macropus eugenii, provides insight into the evolution of mammalian reproduction and development
Marilyn B. Renfree,Marilyn B. Renfree,Anthony T. Papenfuss,Anthony T. Papenfuss,Anthony T. Papenfuss,Janine E. Deakin,Janine E. Deakin,James Lindsay,Thomas N. Heider,Katherine Belov,Katherine Belov,Willem Rens,Paul D. Waters,Paul D. Waters,Elizabeth A. Pharo,Geoff Shaw,Geoff Shaw,Emily S. W. Wong,Emily S. W. Wong,Christophe Lefevre,Kevin R. Nicholas,Yoko Kuroki,Matthew Wakefield,Matthew Wakefield,Kyall R. Zenger,Kyall R. Zenger,Kyall R. Zenger,Chenwei Wang,Chenwei Wang,Malcolm A. Ferguson-Smith,Frank W. Nicholas,Danielle Hickford,Danielle Hickford,Hongshi Yu,Hongshi Yu,Kirsty R. Short,Hannah V. Siddle,Hannah V. Siddle,Stephen Frankenberg,Stephen Frankenberg,Keng Yih Chew,Keng Yih Chew,Brandon R. Menzies,Brandon R. Menzies,Brandon R. Menzies,Jessica M Stringer,Jessica M Stringer,Shunsuke Suzuki,Shunsuke Suzuki,Timothy A. Hore,Timothy A. Hore,Margaret L. Delbridge,Margaret L. Delbridge,A Mohammadi,A Mohammadi,Nanette Y. Schneider,Nanette Y. Schneider,Yanqiu Hu,Yanqiu Hu,William A O'Hara,Shafagh Al Nadaf,Shafagh Al Nadaf,Chen-Chen Wu,Zhi-Ping Feng,Zhi-Ping Feng,Benjamin G. Cocks,Jianghui Wang,Paul Flicek,Stephen M. J. Searle,Susan Fairley,Kathryn Beal,Javier Herrero,Dawn M. Carone,Dawn M. Carone,Yutaka Suzuki,Sumio Sugano,Atsushi Toyoda,Yoshiyuki Sakaki,Shinji Kondo,Yuichiro Nishida,Shoji Tatsumoto,Ion Mandiou,Arthur Hsu,Arthur Hsu,Kaighin A. McColl,Benjamin James Lansdell,George M. Weinstock,Elizabeth Kuczek,Elizabeth Kuczek,Elizabeth Kuczek,Annette McGrath,Peter A Wilson,A. Men,Mehlika Hazar-Rethinam,Allison Hall,John Davis,David L. A. Wood,Sarah E. Williams,Yogi Sundaravadanam,Donna M. Muzny,Shalini N. Jhangiani,Lora Lewis,Margaret Morgan,Geoffrey Okwuonu,San Juana Ruiz,Jireh Santibanez,Lynne V. Nazareth,Andrew Cree,Gerald R. Fowler,Christie Kovar,Huyen Dinh,Vandita Joshi,Chyn Jing,Fremiet Lara,Rebecca Thornton,Lei Chen,Jixin Deng,Yue-E Liu,Joshua Y Shen,Xing-Zhi Henry Song,Janette Edson,Carmen Troon,Daniel Thomas,Amber E. Stephens,Lankesha Yapa,Tanya Levchenko,Richard A. Gibbs,Desmond W. Cooper,Desmond W. Cooper,Terence P. Speed,Terence P. Speed,Asao Fujiyama,Asao Fujiyama,Jennifer A. Marshall Graves,Jennifer A. Marshall Graves,Rachel J. O’Neill,Andrew J Pask,Andrew J Pask,Andrew J Pask,Susan M. Forrest,Susan M. Forrest,Kim C. Worley +141 more
TL;DR: The genome sequence of the tammar wallaby, Macropus eugenii, is presented, which is a member of the kangaroo family and the first representative of the iconic hopping mammals that symbolize Australia to be sequenced, to provide new insight into marsupial and mammalian biology and genome evolution.
Journal ArticleDOI
Genomic and Functional Fidelity of Small Cell Lung Cancer Patient-Derived Xenografts.
Benjamin J. Drapkin,Julie George,Camilla L. Christensen,Mari Mino-Kenudson,Ruben Dries,Tilak K. Sundaresan,Sarah Phat,David T. Myers,Jun Zhong,Peter Igo,Mehlika Hazar-Rethinam,Joseph A. LiCausi,Maria Gomez-Caraballo,Marina Kem,Kandarp Jani,Roxana Azimi,Nima Abedpour,Roopika Menon,Sotirios Lakis,Rebecca S. Heist,Reinhard Büttner,Stefan A. Haas,Lecia V. Sequist,Alice T. Shaw,Kwok-Kin Wong,Aaron N. Hata,Mehmet Toner,Shyamala Maheswaran,Daniel A. Haber,Martin Peifer,Nicholas J. Dyson,Roman K. Thomas,Roman K. Thomas,Anna F. Farago +33 more
TL;DR: Applying an established clinical-translational pipeline for tissue collection and an automated microfluidic platform for CTC enrichment, approaches for efficient generation of PDXs from both biopsies and CTCs are presented, and these models capture the mutational landscape and functional features of the donor tumors.