A
Alicia Wong
Researcher at Broad Institute
Publications - 4
Citations - 614
Alicia Wong is an academic researcher from Broad Institute. The author has contributed to research in topics: Cancer & Prostate. The author has an hindex of 3, co-authored 4 publications receiving 362 citations.
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Journal ArticleDOI
Liquid versus tissue biopsy for detecting acquired resistance and tumor heterogeneity in gastrointestinal cancers.
Aparna Raj Parikh,Ignaty Leshchiner,Liudmila Elagina,Lipika Goyal,Chaya Levovitz,Giulia Siravegna,Dimitri Livitz,Kahn Rhrissorrakrai,Elizabeth E. Martin,Emily E. Van Seventer,Megan Hanna,Kara Slowik,Filippo Utro,Christopher J. Pinto,Alicia Wong,Brian P. Danysh,Ferran Fece de la Cruz,Isobel J Fetter,Brandon Nadres,Heather A. Shahzade,Jill N. Allen,Lawrence S. Blaszkowsky,Jeffrey W. Clark,Bruce J. Giantonio,Janet E. Murphy,Ryan D. Nipp,Eric Roeland,David P. Ryan,Colin D. Weekes,Eunice L. Kwak,Jason E. Faris,Jennifer Y. Wo,François Aguet,Ipsita Dey-Guha,Mehlika Hazar-Rethinam,Dora Dias-Santagata,David T. Ting,Andrew X. Zhu,Theodore S. Hong,Todd R. Golub,Todd R. Golub,Todd R. Golub,A. John Iafrate,Viktor A. Adalsteinsson,Alberto Bardelli,Laxmi Parida,Dejan Juric,Gad Getz,Ryan B. Corcoran +48 more
TL;DR: Direct prospective comparison of circulating tumor DNA and tissue biopsy sequencing shows the superiority of liquid biopsies for capturing clinically relevant alterations mediating resistance to targeted therapies in cancer patients.
Journal ArticleDOI
Structural Alterations Driving Castration-Resistant Prostate Cancer Revealed by Linked-Read Genome Sequencing.
Srinivas R. Viswanathan,Srinivas R. Viswanathan,Gavin Ha,Gavin Ha,Andreas M. Hoff,Andreas M. Hoff,Jeremiah Wala,Jeremiah Wala,Jian Carrot-Zhang,Jian Carrot-Zhang,Christopher W. Whelan,Christopher W. Whelan,Nicholas J. Haradhvala,Nicholas J. Haradhvala,Samuel S. Freeman,Samuel S. Freeman,Sarah C. Reed,Justin Rhoades,Paz Polak,Michelle Cipicchio,Stephanie A. Wankowicz,Stephanie A. Wankowicz,Alicia Wong,Tushar Kamath,Tushar Kamath,Zhenwei Zhang,Gregory Gydush,Denisse Rotem,J. Christopher Love,J. Christopher Love,Gad Getz,Gad Getz,Stacey Gabriel,Cheng-Zhong Zhang,Cheng-Zhong Zhang,Scott M. Dehm,Peter S. Nelson,Eliezer M. Van Allen,Eliezer M. Van Allen,Atish D. Choudhury,Viktor A. Adalsteinsson,Viktor A. Adalsteinsson,Rameen Beroukhim,Mary-Ellen Taplin,Matthew Meyerson +44 more
TL;DR: The findings highlight the complex genomic structure of mCRPC, nominate alterations that may inform prostate cancer treatment, and suggest that additional recurrent events in the non-coding m CRPC genome remain to be discovered.
Journal ArticleDOI
Growth dynamics in naturally progressing chronic lymphocytic leukaemia
Michaela Gruber,Ivana Bozic,Ignaty Leshchiner,Dimitri Livitz,Kristen E. Stevenson,Laura Z. Rassenti,Daniel Rosebrock,Amaro Taylor-Weiner,Oriol Olive,Reaha Goyetche,Stacey M. Fernandes,Jing Sun,Chip Stewart,Alicia Wong,Carrie Cibulskis,Wandi Zhang,Johannes G. Reiter,Jeffrey M. Gerold,John G. Gribben,Kanti R. Rai,Michael J. Keating,Jennifer R. Brown,Jennifer R. Brown,Donna Neuberg,Thomas J. Kipps,Martin A. Nowak,Gad Getz,Catherine J. Wu +27 more
TL;DR: Analysis of growth dynamics in a dataset from 107 patients with chronic lymphocytic leukaemia reveals both exponential and logistic patterns of growth, which are associated with differences in genetic attributes and clinical outcomes.
Proceedings ArticleDOI
Abstract 5371: The Metastatic Breast Cancer Project: Partnering with patients to accelerate progress in cancer research
Nikhil Wagle,Corrie A. Painter,Elana Anastasio,Michael Dunphy,Mary McGillicuddy,Rachel Stoddard,Esha Jain,Dewey Kim,Simona Di Lascio,Brett N. Tompson,Sara Balch,Beena Thomas,Priti Kumari,Shawn F. Johnson,Jamie Holloway,Ofir Cohen,Erik H. Knelson,Katie Larkin,Sam Pollock,Alicia Wong,Samira Bahl,Simone Maiwald,Andrew Zimmer,Esme O. Baker,Jen Lapan,Scott Sutherland,Scott Sassone,Viktor A. Adalsteinsson,Eric S. Lander,Todd R. Golub +29 more
TL;DR: A patient-driven approach enabled rapid identification of thousands of MBC pts willing to share samples and clinical data, and this shared clinico-genomic database should enable research in MBC and may serve as a model for patient- driven research in other cancers.