Karel Šmejkal

TL;DR: Flavonoids, as natural plant antioxidants and essential component of the human diet, are reviewed as compounds interacting with the production of hydroxyl radicals and the structure of the flavonoids is discussed.

TL;DR: In vitro inhibitory activities of four flavonoid derivatives of quercetin, rutin, kaempferol 3-O-beta-D-galactoside and macluraxanthone are examined to show a concentration-dependant inhibition of acetylcholinesterase and BChE and several strong hydrogen bonds to several important amino acid residues of both the enzymes were showed.

TL;DR: A timely overview of the pharmacological properties and therapeutic application of BBR in CVMD is provided, and recent pharmacological advances which validate BBR as a promising lead drug against CVMD are underlined.

TL;DR: The present review aims to serve as an “opening” of this special issue of Molecules, presenting key historical developments, recent advances, and future perspectives outlining the potential of natural products for prevention or therapy of cardiovascular and metabolic disease.

TL;DR: Anti-cancer effects of flavonoids, targeting all phases of carcinogenesis including metastatic progression, should be implemented into clinical cancer research in order to strengthen their potential use in the future targeted prevention and therapy of cancer in high-risk individuals or patients with aggressive cancer disease with metastatic potential.