Karen Inouye

TL;DR: It is suggested that TLR4 is a molecular link among nutrition, lipids, and inflammation and that the innate immune system participates in the regulation of energy balance and insulin resistance in response to changes in the nutritional environment.

TL;DR: Results show a crucial role for PKR in inflammasome activation, and indicate that it should be possible to pharmacologically target this molecule to treat inflammation.

TL;DR: It is shown that in the liver, obesity leads to a marked reorganization of MAMs resulting in mitochondrial calcium overload, compromised mitochondrial oxidative capacity and augmented oxidative stress, whereas downregulation of PACS-2 or IP3R1, proteins important for ER-mitochondria tethering or calcium transport, improves mitochondrial oxidativecapacity and glucose metabolism in obese animals.

TL;DR: It is concluded that CCL2 is not critical for adipose tissue macrophage recruitment, and the dominant factor for recruiting macrophages in adipOSE tissue during obesity remains to be identified.

TL;DR: It is concluded that aP2 is an adipokine linking adipocytes to hepatic glucose production and that neutralizing secreted aP1 may represent an effective therapeutic strategy against diabetes.