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Ben Lu
Researcher at Central South University
Publications - 43
Citations - 3995
Ben Lu is an academic researcher from Central South University. The author has contributed to research in topics: HMGB1 & Caspase-11. The author has an hindex of 20, co-authored 37 publications receiving 3011 citations. Previous affiliations of Ben Lu include North Shore-LIJ Health System & The Feinstein Institute for Medical Research.
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Journal ArticleDOI
A critical cysteine is required for HMGB1 binding to Toll-like receptor 4 and activation of macrophage cytokine release
Huan Yang,Hulda Sigridur Hreggvidsdottir,Karin Palmblad,Haichao Wang,Mahendar Ochani,Jianhua Li,Ben Lu,Sangeeta S. Chavan,Mauricio Rosas-Ballina,Yousef Al-Abed,Shizuo Akira,Angelika Bierhaus,Helena Erlandsson-Harris,Ulf Andersson,Kevin J. Tracey +14 more
TL;DR: It is shown that Toll-like receptor 4 (TLR4), a pivotal receptor for activation of innate immunity and cytokine release, is required for HMGB1-dependent activation of macrophage TNF release.
Journal ArticleDOI
Novel role of PKR in inflammasome activation and HMGB1 release
Ben Lu,Takahisa Nakamura,Karen Inouye,Jianhua Li,Yiting Tang,Peter Lundbäck,Sergio I. Valdés-Ferrer,Peder S. Olofsson,Thomas Kalb,Jesse Roth,Yongrui Zou,Helena Erlandsson-Harris,Huan Yang,Jenny P.-Y. Ting,Haichao Wang,Ulf Andersson,Daniel J. Antoine,Sangeeta S. Chavan,Gökhan S. Hotamisligil,Kevin J. Tracey +19 more
TL;DR: Results show a crucial role for PKR in inflammasome activation, and indicate that it should be possible to pharmacologically target this molecule to treat inflammation.
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The Endotoxin Delivery Protein HMGB1 Mediates Caspase-11-Dependent Lethality in Sepsis
Meihong Deng,Yiting Tang,Wenbo Li,Xiangyu Wang,Rui Zhang,Xianying Zhang,Xin Zhao,Jian Liu,Cheng Tang,Zhonghua Liu,Yongzhuo Huang,Huige Peng,Lehui Xiao,Daolin Tang,Melanie J. Scott,Qingde Wang,Jing Liu,Xianzhong Xiao,Simon C. Watkins,Jianhua Li,Huan Yang,Haichao Wang,Fangping Chen,Kevin J. Tracey,Timothy R. Billiar,Ben Lu +25 more
TL;DR: It is demonstrated that hepatocyte‐released HMGB1 mediates caspase‐11‐dependent pyroptosis and lethality in sepsis by delivering extracellular LPS into the cytosol of macrophages and endothelial cells, where LPS activates casp enzyme‐11.
Journal ArticleDOI
JAK/STAT1 signaling promotes HMGB1 hyperacetylation and nuclear translocation
Ben Lu,Daniel J. Antoine,Kevin Kwan,Peter Lundbäck,Heidi Wähämaa,Hanna Schierbeck,Melissa Robinson,Marieke A. D. van Zoelen,Huan Yang,Jianhua Li,Helena Erlandsson-Harris,Sangeeta S. Chavan,Haichao Wang,Ulf Andersson,Kevin J. Tracey,Kevin J. Tracey,Kevin J. Tracey +16 more
TL;DR: A critical role is identified in mediating HMGB1 cytoplasmic accumulation for subsequent release, suggesting that the JAK/STAT1 pathway is a potential drug target for inhibitingHMGB1 release.
Journal ArticleDOI
MD-2 is required for disulfide HMGB1-dependent TLR4 signaling
Huan Yang,Haichao Wang,Zhongliang Ju,Ahmed A. Ragab,Peter Lundbäck,Wei Long,Sergio I. Valdés-Ferrer,Mingzhu He,John P. Pribis,Jianhua Li,Ben Lu,Domokos Gero,Csaba Szabó,Daniel J. Antoine,Helena Erlandsson Harris,Doug T. Golenbock,Jianmin Meng,Jesse Roth,Sangeeta S. Chavan,Ulf Andersson,Timothy R. Billiar,Kevin J. Tracey,Yousef Al-Abed +22 more
TL;DR: An HGMB1 peptide inhibitor, P5779, which when administered in vivo can protect mice from acetaminophen-induced hepatoxicity, ischemia/reperfusion injury, and sepsis, is identified.