H
Helena Erlandsson-Harris
Researcher at Karolinska University Hospital
Publications - 29
Citations - 5514
Helena Erlandsson-Harris is an academic researcher from Karolinska University Hospital. The author has contributed to research in topics: HMGB1 & Cytokine. The author has an hindex of 22, co-authored 27 publications receiving 5096 citations. Previous affiliations of Helena Erlandsson-Harris include Karolinska Institutet.
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Journal ArticleDOI
High mobility group 1 protein (HMG-1) stimulates proinflammatory cytokine synthesis in human monocytes.
Ulf Andersson,Haichao Wang,Karin Palmblad,Ann-Charlotte Aveberger,Ona Bloom,Helena Erlandsson-Harris,Alfred Janson,R. Kokkola,Minghuang Zhang,Huan Yang,Kevin J. Tracey +10 more
TL;DR: Results indicate that, like other cytokine mediators of endotoxin lethality (e.g., TNF and IL-1), extracellular HMG-1 is a regulator of monocyte proinflammatory cytokine synthesis.
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A critical cysteine is required for HMGB1 binding to Toll-like receptor 4 and activation of macrophage cytokine release
Huan Yang,Hulda Sigridur Hreggvidsdottir,Karin Palmblad,Haichao Wang,Mahendar Ochani,Jianhua Li,Ben Lu,Sangeeta S. Chavan,Mauricio Rosas-Ballina,Yousef Al-Abed,Shizuo Akira,Angelika Bierhaus,Helena Erlandsson-Harris,Ulf Andersson,Kevin J. Tracey +14 more
TL;DR: It is shown that Toll-like receptor 4 (TLR4), a pivotal receptor for activation of innate immunity and cytokine release, is required for HMGB1-dependent activation of macrophage TNF release.
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Novel role of PKR in inflammasome activation and HMGB1 release
Ben Lu,Takahisa Nakamura,Karen Inouye,Jianhua Li,Yiting Tang,Peter Lundbäck,Sergio I. Valdés-Ferrer,Peder S. Olofsson,Thomas Kalb,Jesse Roth,Yongrui Zou,Helena Erlandsson-Harris,Huan Yang,Jenny P.-Y. Ting,Haichao Wang,Ulf Andersson,Daniel J. Antoine,Sangeeta S. Chavan,Gökhan S. Hotamisligil,Kevin J. Tracey +19 more
TL;DR: Results show a crucial role for PKR in inflammasome activation, and indicate that it should be possible to pharmacologically target this molecule to treat inflammation.
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Redox modification of cysteine residues regulates the cytokine activity of high mobility group box-1 (HMGB1).
Huan Yang,Peter Lundbäck,Lars Ottosson,Helena Erlandsson-Harris,Emilie Venereau,Marco Bianchi,Yousef Al-Abed,Ulf Andersson,Kevin J. Tracey,Daniel J. Antoine +9 more
TL;DR: It is established that the C106 thiol and the C23-C45 disulfide bond are required for HMGB1 to induce nuclear NF-κB translocation and tumor necrosis factor (TNF) production in macrophages.
Journal ArticleDOI
High mobility group 1 B‐box mediates activation of human endothelium
Carl Johan Treutiger,G. E. Mullins,A.-S. M. Johansson,Ari Rouhiainen,Ari Rouhiainen,Heikki Rauvala,Helena Erlandsson-Harris,Ulf Andersson,Huan Yang,Kevin J. Tracey,Jan Andersson,Jan Palmblad +11 more
TL;DR: High mobility group 1 B‐box mediates activation of human endothelium in mice and results in down-regulation in mice with high IgA levels.