K
Karen M. Gehrs
Researcher at University of Iowa
Publications - 61
Citations - 6295
Karen M. Gehrs is an academic researcher from University of Iowa. The author has contributed to research in topics: Macular degeneration & Endophthalmitis. The author has an hindex of 28, co-authored 59 publications receiving 5885 citations. Previous affiliations of Karen M. Gehrs include Duke University & Roy J. and Lucille A. Carver College of Medicine.
Papers
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Journal ArticleDOI
A common haplotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to age-related macular degeneration
Gregory S. Hageman,Don H. Anderson,Lincoln V. Johnson,Lisa S. Hancox,Andrew J Taiber,Lisa I. Hardisty,Jill L. Hageman,Heather Stockman,James D. Borchardt,Karen M. Gehrs,Richard J.H. Smith,Giuliana Silvestri,Stephen R. Russell,Caroline C W Klaver,Irene Barbazetto,Stanley Chang,Lawrence A. Yannuzzi,Gaetano R. Barile,John C. Merriam,R. Theodore Smith,Adam Olsh,Julie Bergeron,Jana Zernant,Joanna E. Merriam,Bert Gold,Michael Dean,Rando Allikmets +26 more
TL;DR: It is shown that factor H (HF1), the major inhibitor of the alternative complement pathway, accumulates within drusen and is synthesized by the retinal pigmented epithelium, implicating HF1 function in the pathogenetic mechanisms underlying AMD.
Journal ArticleDOI
Variation in factor B (BF) and complement component 2 (C2) genes is associated with age-related macular degeneration
Bert Gold,Joanna E. Merriam,Jana Zernant,Lisa S. Hancox,Andrew J Taiber,Karen M. Gehrs,Kevin Cramer,Julia Neel,Julie Bergeron,Gaetano R. Barile,R. Theodore Smith,Gregory S. Hageman,Michael Dean,Rando Allikmets +13 more
TL;DR: Combined analysis of the C2 and BF haplotypes and CFH variants shows that variation in the two loci can predict the clinical outcome in 74% of the affected individuals and 56% ofThe controls, expanding and refine the understanding of the genetic risk for AMD.
Journal ArticleDOI
Age-related macular degeneration--emerging pathogenetic and therapeutic concepts.
TL;DR: Recently, compelling evidence has emerged that the innate immune system and, more specifically, uncontrolled regulation of the complement alternative pathway plays a central role in the pathobiology of AMD.
Book
Age-Related Macular Degeneration (AMD)
TL;DR: The macula lutea as mentioned in this paper is a region of the retina that contains the highest density of cone photoreceptor cells and is the only region of retina where 20/20 vision is attainable.
Journal ArticleDOI
Extended haplotypes in the complement factor H (CFH) and CFH‐related (CFHR) family of genes protect against age‐related macular degeneration: Characterization, ethnic distribution and evolutionary implications
Gregory S. Hageman,Gregory S. Hageman,Lisa S. Hancox,Andrew J Taiber,Karen M. Gehrs,Don H. Anderson,Lincoln V. Johnson,Monte J. Radeke,David J. Kavanagh,Anna Richards,John P. Atkinson,Seppo Meri,Julie Bergeron,Jana Zernant,Joanna E. Merriam,Bert Gold,Rando Allikmets,Michael Dean +17 more
TL;DR: The absence of CFHR1 and/or CFHR3 may account for the protective effects conferred by some CFH haplotypes and the high frequencies of the 402H allele and the delCFHR1/CFHR3 alleles in African populations suggest an ancient origin for these alleles.