K
Karine Clément
Researcher at University of Paris
Publications - 334
Citations - 38686
Karine Clément is an academic researcher from University of Paris. The author has contributed to research in topics: Adipose tissue & Medicine. The author has an hindex of 78, co-authored 275 publications receiving 32185 citations. Previous affiliations of Karine Clément include French Institute of Health and Medical Research & Hotel Dieu Hospital.
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Journal ArticleDOI
Hnf4g invalidation prevents diet-induced obesity via intestinal lipid malabsorption.
Sami Ayari,Eva Gil-Iturbe,Léa Le Gléau,Céline Osinski,Nathalie Kapel,Hédi Soula,Armelle Leturque,Fabrizio Andreelli,Karine Clément,Patricia Serradas,Agnès Ribeiro +10 more
TL;DR: In this paper, the role of HNF-4γ in metabolic disorders and related mechanisms was investigated in mice fed with high-fat/high-fructose (HF-HF) diet for 6 weeks.
Posted ContentDOI
The brain's hedonic valuation system's resting-state connectivity predicts weight loss and correlates with leptin
Liane Schmidt,Evelyn Medarwar,Judith Aron-Wisnewsky,Laurent Genser,Christine Poitou,Karine Clément,Hilke Plassmann,Hilke Plassmann +7 more
TL;DR: This research is the first to link what the authors know about the brain’s hedonic valuation system (BVS) to weight loss and homeostatic hormone regulation, and indicates a first link between brain connectivity in reward circuits in a more tonic state at rest and ability to lose weight.
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Deep kernel dimensionality reduction for scalable data integration
TL;DR: This work proposes a novel approach, called Deep Kernel Dimensionality Reduction which is designed for learning layers of new compact data representations simultaneously, and shows that the proposed method embeds data in a new compact meaningful representation, and leads to a lower classification error compared to the state of the art methods.
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Intestinal alteration of α-gustducin and sweet taste signaling pathway in metabolic diseases is partly rescued after weight loss and diabetes remission.
Léa Le Gléau,Christine Rouault,Céline Osinski,Edi Prifti,Hédi Soula,Jean Debédat,Pauline Busieau,Chloé Amouyal,Karine Clément,Fabrizio Andreelli,Agnès Ribeiro,Patricia Serradas +11 more
TL;DR: In this article, the authors highlighted that the sweet taste transduction pathway plays pivotal role for glucose homeostasis at least at gene expression level, and metabolic disorders led to altered gene express...
Journal ArticleDOI
Obésité humaine: vers les approches génomiques fonctionnelles.
TL;DR: In this article, the authors present some examples of the knowledge acquired in the field of obesity genetics and the new ongoing tools and developments that aim at studying the contribution of genes to obesity and their response to environmental changes.