K
Karine Clément
Researcher at University of Paris
Publications - 334
Citations - 38686
Karine Clément is an academic researcher from University of Paris. The author has contributed to research in topics: Adipose tissue & Medicine. The author has an hindex of 78, co-authored 275 publications receiving 32185 citations. Previous affiliations of Karine Clément include French Institute of Health and Medical Research & Hotel Dieu Hospital.
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Journal ArticleDOI
GAD2 on Chromosome 10p12 Is a Candidate Gene for Human Obesity
Philippe Boutin,Christian Dina,Francis Vasseur,Séverine Dubois,Laetitia Corset,Karin Séron,Lynn M. Bekris,Janice Cabellon,Bernadette Neve,Valérie Vasseur-Delannoy,Mohamed Chikri,M. Aline Charles,Karine Clément,Åke Lernmark,Philippe Froguel +14 more
TL;DR: The hypothesis of the orexigenic effect of GABA in humans and of a contribution of genes involved in GABA metabolism in the modulation of food intake and in the development of morbid obesity are supported.
Journal ArticleDOI
The case for strategic international alliances to harness nutritional genomics for public and personal health
Jim Kaput,Jose M. Ordovas,Lynnette R. Ferguson,Ben van Ommen,Raymond L. Rodriguez,Lindsay H. Allen,Bruce N. Ames,Kevin Dawson,Bruce German,Ronald M. Krauss,Wasyl Malyj,Michael C. Archer,Stephen Barnes,Amelia Bartholomew,Ruth Birk,Peter J. van Bladeren,Kent J. Bradford,Kenneth H. Brown,Rosane Caetano,David Castle,Ruth Chadwick,Stephen L. Clarke,Karine Clément,Craig A. Cooney,Dolores Corella,Ivana Beatrice Manica da Cruz,Hannelore Daniel,Troy Duster,Sven O. E. Ebbesson,Ruan M. Elliott,Susan J. Fairweather-Tait,Jim Felton,Michael Fenech,John W. Finley,Nancy Fogg-Johnson,Rosalynn Gill-Garrison,Michael J. Gibney,Gillies Peter John,Jan-Åke Gustafsson,John L. Hartman,Lin He,Jae-Kwan Hwang,Jean-Philippe Jais,Yangsoo Jang,Hans Joost,Claudine Junien,Mitchell M. Kanter,Warren A. Kibbe,Berthold Koletzko,Bruce R. Korf,Kenneth S. Kornman,David W. Krempin,Dominique Langin,Denis R. Lauren,Jong Ho Lee,Gilbert A. Leveille,Su-Ju Lin,John C. Mathers,Michael Mayne,Warren C. McNabb,John A. Milner,Peter Morgan,Michael Müller,Yuri Nikolsky,Frans van der Ouderaa,Taesun Park,Norma Ana Pensel,Francisco Pérez-Jiménez,Kaisa Poutanen,Matthew A. Roberts,Wim H. M. Saris,Gertrud U. Schuster,Andrew N. Shelling,Artemis P. Simopoulos,Sue Southon,E. Shyong Tai,Bradford Towne,Paul Trayhurn,Ricardo Uauy,Willard J. Visek,Craig H Warden,Rick Weiss,John K. Wiencke,Jack Winkler,George L. Wolff,Xi Zhao-Wilson,Jean-Daniel Zucker +86 more
TL;DR: In this paper, the authors provide specific recommendations for how to best meet this challenge and discuss the need for new methodologies and the use of comprehensive analyses of nutrient-genotype interactions involving large and diverse populations.
Journal ArticleDOI
Serum amyloid A: production by human white adipocyte and regulation by obesity and nutrition
Christine Poitou,Nathalie Viguerie,Raffaella Cancello,R. De Matteis,Saverio Cinti,Vladimir Stich,Christiane Coussieu,E. Gauthier,Mélanie Courtine,Mélanie Courtine,Jean-Daniel Zucker,Jean-Daniel Zucker,Gregory S. Barsh,Wim H. M. Saris,P. Bruneval,Arnaud Basdevant,Dominique Langin,Karine Clément +17 more
TL;DR: The results of the present study indicate that SAA is expressed by sWAT, and its production at this site is regulated by nutritional status.
Journal ArticleDOI
Genome wide association study identifies KCNMA1 contributing to human obesity
Hong Jiao,Hong Jiao,Peter Arner,Johan Hoffstedt,David Brodin,Béatrice Dubern,Sébastien Czernichow,Ferdinand M. van't Hooft,Tomas Axelsson,Oluf Pedersen,Torben Hansen,Thorkild I. A. Sørensen,Johannes Hebebrand,Juha Kere,Juha Kere,Karin Dahlman-Wright,Anders Hamsten,Karine Clément,Ingrid Dahlman +18 more
TL;DR: The association of KCNMA1 with BDNF was identified as a new susceptibility locus for obesity, and the association of the BDNF locus at the genome-wide significant level was confirmed.
Journal ArticleDOI
Transcriptomic profiling across the nonalcoholic fatty liver disease spectrum reveals gene signatures for steatohepatitis and fibrosis.
Olivier Govaere,Simon Cockell,Dina Tiniakos,Dina Tiniakos,Rachel Queen,Ramy Younes,Ramy Younes,Michele Vacca,Leigh Alexander,Federico Ravaioli,Federico Ravaioli,Jeremy M. Palmer,Salvatore Petta,Jérôme Boursier,Chiara Rosso,Katherine Johnson,Kristy Wonders,Christopher P. Day,Mattias Ekstedt,Matej Orešič,Rebecca Darlay,Heather J. Cordell,Fabio Marra,Antonio Vidal-Puig,Pierre Bedossa,Pierre Bedossa,Jörn M. Schattenberg,Karine Clément,Michael Allison,Elisabetta Bugianesi,Vlad Ratziu,Ann K. Daly,Quentin M. Anstee +32 more
TL;DR: Analysis of gene expression during human NAFLD progression provides insights into the pathophysiology of progressive fibrosing steatohepatitis, and proof of principle that transcriptomic changes represent potentially tractable and clinically relevant markers of disease progression is provided.