K
Karine Clément
Researcher at University of Paris
Publications - 334
Citations - 38686
Karine Clément is an academic researcher from University of Paris. The author has contributed to research in topics: Adipose tissue & Medicine. The author has an hindex of 78, co-authored 275 publications receiving 32185 citations. Previous affiliations of Karine Clément include French Institute of Health and Medical Research & Hotel Dieu Hospital.
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Journal ArticleDOI
The melanocortin pathway and energy homeostasis: From discovery to obesity therapy.
Giles S.H. Yeo,Daniela Herrera Moro Chao,Anna Maria Siegert,Zoe M. Koerperich,Mark D. Ericson,Stephanie E. Simonds,Courtney M Larson,Serge Luquet,Iain J. Clarke,Shubh D. Sharma,Karine Clément,Michael A. Cowley,Carrie Haskell-Luevano,Lex H.T. Van der Ploeg,Roger A.H. Adan +14 more
TL;DR: In this article, the authors chart the history of the melanocortin pathway, explore its pharmacology, genetics and physiology, and tell the story of how a neuropeptidergic circuit managed to find its way to becoming an important druggable obesity target.
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Use of HOMA-IR to diagnose non-alcoholic fatty liver disease: a population-based and inter-laboratory study
Elina Isokuortti,You Zhou,Markku Peltonen,Elisabetta Bugianesi,Karine Clément,Karine Clément,Dominique Bonnefont-Rousselot,Jean-Marc Lacorte,Jean-Marc Lacorte,Amalia Gastaldelli,Detlef Schuppan,JM Schattenberg,Antti Hakkarainen,Nina Lundbom,Pekka Jousilahti,Satu Männistö,Sirkka Keinänen-Kiukaanniemi,Juha Saltevo,Quentin M. Anstee,Quentin M. Anstee,Hannele Yki-Järvinen,Hannele Yki-Järvinen +21 more
TL;DR: In this article, the upper 95th percentile of HOMA-IR was defined for non-alcoholic fatty liver disease (NAFLD) in two population-based cohorts (FINRISK 2007 [n = 5024] and the Programme for Prevention of Type 2 Diabetes in Finland [FIN-D2D; n = 2849).
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Fecal Microbiota Transplantation: a Future Therapeutic Option for Obesity/Diabetes?
TL;DR: FMT from lean donors significantly improves insulin sensitivity in obese subjects with metabolic syndrome and when FMT donors that are metabolically compromised are used, no metabolic improvement is seen and there is a wide range of clinical responses.
Journal ArticleDOI
Transcriptomics applied to obesity and caloric restriction
Nathalie Viguerie,Christine Poitou,Raffaella Cancello,Vladimir Stich,Karine Clément,Dominique Langin,Dominique Langin +6 more
TL;DR: Modulation of the inflammatory pathways may represent new therapeutic targets for the treatment of obesity-related complications.
Journal ArticleDOI
Acyl-CoA-Binding Protein Is a Lipogenic Factor that Triggers Food Intake and Obesity.
José Manuel Bravo-San Pedro,José Manuel Bravo-San Pedro,Valentina Sica,Valentina Sica,Isabelle Martins,Isabelle Martins,Jonathan Pol,Jonathan Pol,Friedemann Loos,Friedemann Loos,Maria Chiara Maiuri,Maria Chiara Maiuri,Sylvère Durand,Sylvère Durand,Noélie Bossut,Noélie Bossut,Fanny Aprahamian,Fanny Aprahamian,Gerasimos Anagnostopoulos,Mireia Niso-Santano,Fernando Aranda,Ignacio Ramírez-Pardo,Justine Lallement,Jessica Denom,Erwan Boedec,Erwan Boedec,Erwan Boedec,Philip Gorwood,Nicolas Ramoz,Karine Clément,Véronique Pelloux,Alili Rohia,François Pattou,Violeta Raverdy,Robert Caiazzo,Raphaël G. P. Denis,Patricia Boya,Lorenzo Galluzzi,Frank Madeo,Stéphanie Migrenne-Li,Céline Cruciani-Guglielmacci,Nektarios Tavernarakis,Nektarios Tavernarakis,Carlos López-Otín,Carlos López-Otín,Christophe Magnan,Guido Kroemer +46 more
TL;DR: neutralization of ACBP enhanced autophagy, stimulated fatty acid oxidation, inhibited appetite, reduced weight gain in the context of a high-fat diet or leptin deficiency, and accelerated weight loss in response to dietary changes.