L
Laurent Genser
Researcher at University of Paris
Publications - 124
Citations - 1688
Laurent Genser is an academic researcher from University of Paris. The author has contributed to research in topics: Medicine & Sleeve gastrectomy. The author has an hindex of 17, co-authored 102 publications receiving 1151 citations. Previous affiliations of Laurent Genser include Institute of Chartered Accountants of Nigeria & Sorbonne.
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Journal ArticleDOI
Mucosal-associated invariant T cell alterations in obese and type 2 diabetic patients
Isabelle Magalhaes,Karine Pingris,Christine Poitou,Stéphanie Bessoles,Nicolas Venteclef,Badr Kiaf,Lucie Beaudoin,Jennifer Da Silva,Omran Allatif,Jamie Rossjohn,Lars Kjer-Nielsen,James McCluskey,Séverine Ledoux,Laurent Genser,Adriana Torcivia,Claire Soudais,Olivier Lantz,Christian Boitard,Judith Aron-Wisnewsky,Etienne Larger,Karine Clément,Agnès Lehuen +21 more
TL;DR: In this paper, the authors analyzed Mucosal-associated invariant T (MAIT) cells in the blood and adipose tissues of patients with Type 2 diabetes and/or severe obesity.
Journal ArticleDOI
Jejunal T Cell Inflammation in Human Obesity Correlates with Decreased Enterocyte Insulin Signaling
Milena Monteiro-Sepulveda,Milena Monteiro-Sepulveda,Milena Monteiro-Sepulveda,Sothea Touch,Sothea Touch,Sothea Touch,Carla Mendes-Sá,Carla Mendes-Sá,Sébastien André,Sébastien André,Sébastien André,Christine Poitou,Omran Allatif,Omran Allatif,Omran Allatif,Aurelie Cotillard,Aurelie Cotillard,Aurelie Cotillard,Hélène Fohrer-Ting,Hélène Fohrer-Ting,Edwige-Ludiwyne Hubert,Edwige-Ludiwyne Hubert,Edwige-Ludiwyne Hubert,Romain Remark,Romain Remark,Laurent Genser,Joan Tordjman,Joan Tordjman,Joan Tordjman,Kevin Garbin,Kevin Garbin,Céline Osinski,Céline Osinski,Catherine Sautès-Fridman,Catherine Sautès-Fridman,Armelle Leturque,Armelle Leturque,Armelle Leturque,Karine Clément,Edith Brot-Laroche,Edith Brot-Laroche,Edith Brot-Laroche +41 more
TL;DR: Obesity triggers T-cell-mediated inflammation and enterocyte insulin resistance in the jejunum with potential broader systemic implications, and statistical links between T cell densities and BMI, NAFLD, or lipid metabolism suggest tissue crosstalk.
Journal ArticleDOI
Increased jejunal permeability in human obesity is revealed by a lipid challenge and is linked to inflammation and type 2 diabetes.
Laurent Genser,Doriane Aguanno,Hédi Soula,Liping Dong,Laurence Trystram,Karen E. Assmann,Joe-Elie Salem,Jean-Christophe Vaillant,Jean-Michel Oppert,Fabienne Laugerette,Marie-Caroline Michalski,Philippe Wind,Monique Rousset,Edith Brot-Laroche,Armelle Leturque,Karine Clément,Sophie Thenet,Christine Poitou +17 more
TL;DR: Inter intestinal barrier defects are present in human severe obesity and exacerbated by a lipid challenge, which paves the way to the development of novel therapeutic approaches to modulate intestinal barrier function or personalize nutrition therapy to decrease lipid‐induced jejunal leakage in metabolic diseases.
Journal ArticleDOI
The advanced-DiaRem score improves prediction of diabetes remission 1 year post-Roux-en-Y gastric bypass.
Judith Aron-Wisnewsky,Nataliya Sokolovska,Yuejun Liu,Doron Comaneshter,Shlomo Vinker,Shlomo Vinker,Tal Pecht,Christine Poitou,Jean-Michel Oppert,Jean-Luc Bouillot,Laurent Genser,Dror Dicker,Dror Dicker,Jean-Daniel Zucker,Assaf Rudich,Karine Clément +15 more
TL;DR: The Ad-DiaRem is proposed, which includes two additional clinical variables, as an optimised tool with improved accuracy to predict diabetes remission 1 year post-RYGB, and might be helpful for personalised management of individuals with diabetes when considering bariatric surgery in routine care.
Journal ArticleDOI
Long-term Relapse of Type 2 Diabetes After Roux-en-Y Gastric Bypass: Prediction and Clinical Relevance
Jean Debédat,Nataliya Sokolovska,Nataliya Sokolovska,Muriel Coupaye,Simona Panunzi,Rima Chakaroun,Laurent Genser,Garance de Turenne,Jean-Luc Bouillot,Christine Poitou,Jean-Michel Oppert,Matthias Blüher,Michael Stumvoll,Geltrude Mingrone,Geltrude Mingrone,Séverine Ledoux,Jean-Daniel Zucker,Jean-Daniel Zucker,Jean-Daniel Zucker,Karine Clément,Karine Clément,Judith Aron-Wisnewsky,Judith Aron-Wisnewsky +22 more
TL;DR: A scoring method, 5-year Advanced-Diabetes Remission (5y-Ad-DiaRem), predicting longer-term DR postsurgery by integrating medical history, bioclinical data, and antidiabetic treatments accurately predicts 5y-DR and appears relevant to identify patients at risk for relapse.