T
Teresa C.F. Assumpção
Researcher at National Institutes of Health
Publications - 22
Citations - 815
Teresa C.F. Assumpção is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Triatoma & Sialome. The author has an hindex of 18, co-authored 22 publications receiving 680 citations. Previous affiliations of Teresa C.F. Assumpção include University of Brasília.
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Journal ArticleDOI
An insight into the sialome of the blood-sucking bug Triatoma infestans, a vector of Chagas' disease
Teresa C.F. Assumpção,Ivo M.B. Francischetti,John F. Andersen,Alexandra Schwarz,Jaime M. Santana,José M. C. Ribeiro +5 more
TL;DR: Most salivary proteins described as lipocalins matched peptide sequences obtained from proteomic results, most of which coded for proteins of a putative secretory nature.
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Salivary Antigen-5/CAP Family Members Are Cu2+-dependent Antioxidant Enzymes That Scavenge O2⨪ and Inhibit Collagen-induced Platelet Aggregation and Neutrophil Oxidative Burst *
Teresa C.F. Assumpção,Dongying Ma,Alexandra Schwarz,Karine Reiter,Jaime M. Santana,John F. Andersen,José M. C. Ribeiro,Glenn Nardone,Lee L. Yu,Ivo M.B. Francischetti +9 more
TL;DR: Antigen-5/CAP emerges as a novel family of Cu2+-dependent antioxidant enzymes that inhibit neutrophil oxidative burst and negatively modulate platelet aggregation by a unique salivary mechanism.
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Lufaxin, a Novel Factor Xa Inhibitor From the Salivary Gland of the Sand Fly Lutzomyia longipalpis, Blocks Protease-Activated Receptor 2 Activation and Inhibits Inflammation and Thrombosis In Vivo
Nicolas Collin,Teresa C.F. Assumpção,Daniella M. Mizurini,Dana C. Gilmore,Angélica Dutra-Oliveira,Michalis Kotsyfakis,Anderson Sá-Nunes,Clarissa Teixeira,José M. C. Ribeiro,Robson Q. Monteiro,Jesus G. Valenzuela,Ivo M.B. Francischetti +11 more
TL;DR: Salivary gland of sand flies was found to inhibit FXa and to interact with the enzyme, and Lufaxin belongs to a novel family of slow-tight FXa inhibitors, which display antithrombotic and anti-inflammatory activities.
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Desmolaris, a novel factor XIa anticoagulant from the salivary gland of the vampire bat (Desmodus rotundus) inhibits inflammation and thrombosis in vivo
Dongying Ma,Daniella M. Mizurini,Teresa C.F. Assumpção,Yuan Li,Yanwei Qi,Michail Kotsyfakis,José M. C. Ribeiro,Robson Q. Monteiro,Ivo M.B. Francischetti +8 more
TL;DR: Results imply that FXIa is the primary in vivo target for Desmolaris at antithrombotic concentrations, under conditions in which the coagulation activation, particularly the contact pathway, plays a major pathological role.
Journal ArticleDOI
Insight into the salivary transcriptome and proteome of Dipetalogaster maxima.
Teresa C.F. Assumpção,Sébastien Charneau,Paula Beatriz Santiago,Ivo M.B. Francischetti,Zhaojing Meng,Carla Nunes de Araújo,Van My Pham,Rayner M. L. Queiroz,Cleudson Nery de Castro,Carlos André Ornelas Ricart,Jaime M. Santana,José M. C. Ribeiro +11 more
TL;DR: The redundancy of sequence identification of saliva-secreted proteins suggests that proteins are present in multiple isoforms or derive from gene duplications, including anticlotting, antiplatelet, and vasodilatory molecules.