Martin K. Selig

TL;DR: The finding that the VEGF promoter of nontransformed cells is strongly activated by the tumor microenvironment points to a need to analyze and understand stromal cell collaboration in tumor angiogenesis.

TL;DR: Findings reveal the specific involvement of immature osteoblast precursors in the coupled vascular and osteogenic transformation essential to endochondral bone development and repair.

TL;DR: It is found that Paneth cells, a key constituent of the mammalian intestinal stem-cell (ISC) niche, augment stem- cell function in response to calorie restriction and mTORC1 non-cell-autonomously regulates stem- Cell self-renewal.

TL;DR: The results identify the MiT/TFE proteins as master regulators of metabolic reprogramming in pancreatic cancer and demonstrate that transcriptional activation of clearance pathways converging on the lysosome is a novel hallmark of aggressive malignancy.

TL;DR: It is shown that high-fat diet (HFD)-induced obesity augments the numbers and function of Lgr5+ intestinal stem cells of the mammalian intestine and highlights how diet-modulated PPAR-δ activation alters not only the function of intestinal stem and progenitor cells, but also their capacity to initiate tumours.