K
Katherine A. Siminovitch
Researcher at Lunenfeld-Tanenbaum Research Institute
Publications - 201
Citations - 18546
Katherine A. Siminovitch is an academic researcher from Lunenfeld-Tanenbaum Research Institute. The author has contributed to research in topics: Genome-wide association study & Protein tyrosine phosphatase. The author has an hindex of 69, co-authored 191 publications receiving 17018 citations. Previous affiliations of Katherine A. Siminovitch include Karolinska Institutet & University of Toronto.
Papers
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Journal ArticleDOI
Hepatocyte-Specific Ptpn6 Deletion Protects From Obesity-Linked Hepatic Insulin Resistance
Elaine Xu,Alexandre Charbonneau,Yannève Rolland,Kerstin Bellmann,Lily I. Pao,Katherine A. Siminovitch,Benjamin G. Neel,Nicole Beauchemin,André Marette +8 more
TL;DR: Results show that hepatocyte Shp1 plays a critical role in the development of hepatic insulin resistance and represents a novel therapeutic target for obesity-linked diabetes.
Journal ArticleDOI
Prevalence and Clinical Implication of Double Mutations in Hypertrophic Cardiomyopathy: Revisiting the Gene-Dose Effect.
Dana Fourey,Melanie Care,Katherine A. Siminovitch,Adaya Weissler-Snir,Waseem Hindieh,Raymond H. Chan,Michael H. Gollob,Harry Rakowski,Arnon Adler +8 more
TL;DR: In this article, a literature search was performed for all studies with information on prevalence and outcome of patients with double mutations and found that double mutations are not rare and are associated with a more severe phenotype.
Journal ArticleDOI
Meta-analysis of genetic polymorphisms in granulomatosis with polyangiitis (Wegener's) reveals shared susceptibility loci with rheumatoid arthritis
Sharon A. Chung,Gang Xie,Delnaz Roshandel,Richard Sherva,Jeffrey C. Edberg,Megan Kravitz,Paul F. Dellaripa,Gary S. Hoffman,Alfred Mahr,Alfred Mahr,Philip Seo,Ulrich Specks,Robert Spiera,E. William St. Clair,John H. Stone,Robert M. Plenge,Katherine A. Siminovitch,Peter A. Merkel,Paul A. Monach +18 more
TL;DR: Genetic polymorphisms in CTLA4 were significantly associated with GPA in the single-marker meta-analysis, suggesting that rheumatoid arthritis and GPA may arise from a similar genetic predisposition.
Book ChapterDOI
Pharmacogenetics of the G protein-coupled receptors.
Miles D. Thompson,David E. C. Cole,Valérie Capra,Katherine A. Siminovitch,G. Enrico Rovati,W. McIntyre Burnham,Brinda K. Rana +6 more
TL;DR: The large body of experimental data generated on structure and function relationships and receptor-ligand interactions are being harnessed for the in silico functional prediction of naturally occurring GPCR variants.
Journal ArticleDOI
Association of the OCTN1/1672T variant with increased risk for colorectal cancer in young individuals and ulcerative colitis patients
Maurizio Martini,Anna Maria Ferrara,Manuela Giachelia,Emiliano Panieri,Katherine A. Siminovitch,Tommaso Galeotti,Luigi Maria Larocca,Giovambattista Pani +7 more
TL;DR: The data demonstrate that OCTN1 could have a role in modulating the severity of chronic inflammation associated with SCC in early age and in UC patients, and that its polymorphisms may help to predict malignant progression of IBD.