K
Katherine A. Siminovitch
Researcher at Lunenfeld-Tanenbaum Research Institute
Publications - 201
Citations - 18546
Katherine A. Siminovitch is an academic researcher from Lunenfeld-Tanenbaum Research Institute. The author has contributed to research in topics: Genome-wide association study & Protein tyrosine phosphatase. The author has an hindex of 69, co-authored 191 publications receiving 17018 citations. Previous affiliations of Katherine A. Siminovitch include Karolinska Institutet & University of Toronto.
Papers
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Journal ArticleDOI
Prenatal diagnosis and genetic analysis of Wiskott–Aldrich syndrome
Journal Article
X chromosome dose and sex bias in autoimmune diseases: increased 47,XXX in systemic lupus erythematosus and Sjögren’s syndrome (BA4P.211)
Ke Liu,Ke Liu,Biji T. Kurien,Biji T. Kurien,Biji T. Kurien,Sarah L. Zimmerman,Kenneth M. Kaufman,Kenneth M. Kaufman,Xavier Mariette,Leah C. Kottyan,Roland Jonsson,Roland Jonsson,Wan-Fai Ng,Roald Omdal,Maureen Rischmueller,Marie Wahren-Herlenius,Judith A. James,Judith A. James,Christopher J. Lessard,Christopher J. Lessard,Susan D. Thompson,Patrick M. Gaffney,Courtney Montgomery,Courtney Montgomery,Katherine A. Siminovitch,Katherine A. Siminovitch,Jeffrey C. Edberg,Robert P. Kimberly,Betty P. Tsao,W J McCune,Jane E. Salmon,Jane E. Salmon,Kathy L. Sivils,Kathy L. Sivils,John B. Harley,John B. Harley,John B. Harley,R. H. Scofield,R. H. Scofield,R. H. Scofield +39 more
TL;DR: Prevalence of 47,XXX was present in excess among SLE and SS subjects as predicted by X chromosome dose effect and multiple pathways to such a bias in autoimmunity were identified.
Selective impairment of CD43-mediated T cell activation in the Wiskott-Aldrich syndrome.
TL;DR: In this paper, the Wiskott-Aldrich syndrome (WAS) is associated with defective glycosylation and altered membrane expression of the leukocyte sialoglycoprotein CD43.
Journal ArticleDOI
A coupled assay for UDP-GlcNAc:Galβ1-3GalNAc-R β1,6-N-acetylglucosaminyltransferase (GlcNAc to GalNAc)
Alessandro Datti,Alessandro Datti,Aldo Orlacchio,Katherine A. Siminovitch,Katherine A. Siminovitch,James W. Dennis,James W. Dennis +6 more
TL;DR: A coupled-enzyme assay for core 2 GlcNAc-T is developed that is approximately 100 times more sensitive than the standard assay using UDP-[ 3 H]Glc NAc as a sugar donor and Galβ1-3GalNAcα-paranitrophenyl (pNp) as acceptor.
Journal ArticleDOI
Glutamate and synaptic plasticity systems and smoking behavior: results from a genetic association study.
Vanessa Argondizo dos Santos,José Miguel Chatkin,Claiton H.D. Bau,Vanessa Rodrigues Paixão-Côrtes,Ye Sun,Ye Sun,Noe Zamel,Katherine A. Siminovitch,Katherine A. Siminovitch +8 more
TL;DR: Two SNPs studied, in the SLC1A2 and ACTN1 genes, were associated with smoking behavior in the study population and are biologically plausible candidates that merit further molecular analyses so as to clarify their potential role in smoking behavior.