K
Katherine A. Siminovitch
Researcher at Lunenfeld-Tanenbaum Research Institute
Publications - 201
Citations - 18546
Katherine A. Siminovitch is an academic researcher from Lunenfeld-Tanenbaum Research Institute. The author has contributed to research in topics: Genome-wide association study & Protein tyrosine phosphatase. The author has an hindex of 69, co-authored 191 publications receiving 17018 citations. Previous affiliations of Katherine A. Siminovitch include Karolinska Institutet & University of Toronto.
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Journal ArticleDOI
Integration of sequence data from a consanguineous family with genetic data from an outbred population identifies PLB1 as a candidate rheumatoid arthritis risk gene
Yukinori Okada,Dorothee Diogo,Dorothee Diogo,Jeff Greenberg,Faten Mouassess,Walid A L Achkar,Robert S. Fulton,Joshua C. Denny,Namrata Gupta,Daniel B. Mirel,S. Gabriel,Gang Li,Joel M. Kremer,Dimitrios A. Pappas,Robert J. Carroll,Anne E. Eyler,Gosia Trynka,Gosia Trynka,Eli A. Stahl,Jing Cui,Richa Saxena,Marieke J H Coenen,Henk-Jan Guchelaar,Tom W J Huizinga,Philippe Dieudé,Xavier Mariette,Anne Barton,Helena Canhão,João Eurico Fonseca,Niek de Vries,Paul P. Tak,Larry W. Moreland,S. Louis Bridges,Corinne Miceli-Richard,Hyon K. Choi,Hyon K. Choi,Yoichiro Kamatani,Pilar Galan,Mark Lathrop,Towfique Raj,Towfique Raj,Philip L. De Jager,Philip L. De Jager,Soumya Raychaudhuri,Jane Worthington,Leonid Padyukov,Lars Klareskog,Katherine A. Siminovitch,Peter K. Gregersen,Elaine R. Mardis,Thurayya Arayssi,L. Kazkaz,Robert M. Plenge,Robert M. Plenge +53 more
TL;DR: It is demonstrated that rare, low-frequency and common alleles at one gene locus, phospholipase B1 (PLB1), might contribute to risk of RA in a 4-generation consanguineous pedigree and also in unrelated individuals from the general population (European ancestry).
Journal ArticleDOI
The SHP-1 protein tyrosine phosphatase negatively modulates glucose homeostasis
Marie-Julie Dubois,Sébastien Bergeron,Hyo-Jeong Kim,Hyo-Jeong Kim,Luce Dombrowski,Mylène Perreault,Bénédicte Fournès,Robert Faure,Martin Olivier,Nicole Beauchemin,Gerald I. Shulman,Gerald I. Shulman,Katherine A. Siminovitch,Jason K. Kim,André Marette +14 more
TL;DR: A novel role for SHP-1 is shown in the regulation of glucose homeostasis through modulation of insulin signaling in liver and muscle as well as hepatic insulin clearance.
Journal ArticleDOI
Immunochip analyses identify a novel risk locus for primary biliary cirrhosis at 13q14, multiple independent associations at four established risk loci and epistasis between 1p31 and 7q32 risk variants
Brian D. Juran,Gideon M. Hirschfield,Pietro Invernizzi,Elizabeth J. Atkinson,Yafang Li,Gang Xie,Roman Kosoy,Michael Ransom,Ye Sun,Ilaria Bianchi,Erik M. Schlicht,Ana Lleo,Catalina Coltescu,Francesca Bernuzzi,Mauro Podda,Craig Lammert,Russell Shigeta,Landon L. Chan,Tobias Balschun,Maurizio Marconi,Daniele Cusi,E. Jenny Heathcote,Andrew Mason,Robert P. Myers,Piotr Milkiewicz,Joseph A. Odin,Velimir A. Luketic,Bruce R. Bacon,Henry C. Bodenheimer,Valentina Liakina,Catherine Vincent,Cynthia Levy,Andre Franke,Peter K. Gregersen,Fabrizio Bossa,M. Eric Gershwin,Mariza deAndrade,Christopher I. Amos,Konstantinos N. Lazaridis,Michael F. Seldin,Katherine A. Siminovitch +40 more
TL;DR: To further characterize the genetic basis of primary biliary cirrhosis (PBC), genotyped patients and unaffected controls using a single nucleotide polymorphism array (Immunochip) enriched for autoimmune disease risk loci and identified a novel disease-associated locus near the TNFSF11 gene at 13q14.
Journal ArticleDOI
Association of Granulomatosis With Polyangiitis (Wegener's) With HLA–DPB1*04 and SEMA6A Gene Variants: Evidence From Genome-Wide Analysis
Gang Xie,Delnaz Roshandel,Richard Sherva,Paul A. Monach,Emily Y. Lu,Tabitha N. Kung,Keisha Carrington,Steven S. Zhang,Sara L. Pulit,Stephan Ripke,Simon Carette,Paul F. Dellaripa,Jeffrey C. Edberg,Gary S. Hoffman,Nader Khalidi,Carol A. Langford,Alfred Mahr,E. William St. Clair,Philip Seo,Ulrich Specks,Robert Spiera,John H. Stone,Steven R. Ytterberg,Soumya Raychaudhuri,Soumya Raychaudhuri,Paul I.W. de Bakker,Lindsay A. Farrer,Christopher I. Amos,Christopher I. Amos,Peter A. Merkel,Peter A. Merkel,Katherine A. Siminovitch,Katherine A. Siminovitch +32 more
TL;DR: In this paper, the authors carried out a genome-wide association study (GWAS) of 492 Wegener's patients and 1,506 healthy controls (white subjects of European descent), followed by replication analysis of the most strongly associated signals.
Journal ArticleDOI
The intersectin 2 adaptor links Wiskott Aldrich Syndrome protein (WASp)-mediated actin polymerization to T cell antigen receptor endocytosis.
Mary K. H. McGavin,Karen Badour,Karen Badour,Lynne A. Hardy,Lynne A. Hardy,Terrance J. Kubiseski,Jinyi Zhang,Jinyi Zhang,Katherine A. Siminovitch,Katherine A. Siminovitch +9 more
TL;DR: Intersectin 2 appears to function cooperatively with WASp and cdc42 to link the clathrin endocytic machinery to WASp-mediated actin polymerization and ultimately to occupancy-induced TCR endocytosis.