Kathleen D. Mansfield

TL;DR: Major tumour regressions are reported in a subset of patients with metastatic melanoma treated with an anti-CTLA4 antibody and radiation and reproduced this effect in mouse models, showing that PD-L1 on melanoma cells allows tumours to escape anti- NCTLA4-based therapy, and the combination of radiation, anti- CTLA4 and anti-PD-L 1 promotes response and immunity through distinct mechanisms.

TL;DR: Future rational vaccine design efforts should incorporate Tfh measurement as an immune correlate of protection, particularly in the setting of aging.

TL;DR: In this article, the authors identified MNV-specific major histocompatibility complex (MHC) class I immunodominant epitopes using an overlapping peptide screen.

TL;DR: It is demonstrated that increased percentages of CD8 T cells from aged individuals express CD57 and KLRG1, along with PD‐1 and other inhibitory receptors, markers of senescence, or exhaustion, respectively, which suggest a prominent role forsenescence and/or terminal differentiation for influenza virus‐specific CD8T cells in elderly subjects.

TL;DR: Accumulation of pre-existing influenza virus-specific immunity in the form of NAb and cross-reactive T cells to conserved virus proteins over a lifetime of exposure to infection and vaccination may influence vaccine-induced CD4 T cell responses in the aged.