K
Kathleen D. Mansfield
Researcher at University of Pennsylvania
Publications - 7
Citations - 2208
Kathleen D. Mansfield is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Cytotoxic T cell & Antigen. The author has an hindex of 6, co-authored 7 publications receiving 1813 citations.
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Journal ArticleDOI
Radiation and dual checkpoint blockade activate non-redundant immune mechanisms in cancer
Christina Twyman-Saint Victor,Andrew J. Rech,Amit Maity,Ramesh Rengan,Ramesh Rengan,Kristen E. Pauken,Erietta Stelekati,Joseph L. Benci,Bihui Xu,Hannah Dada,Pamela M. Odorizzi,Ramin S. Herati,Kathleen D. Mansfield,Dana Patsch,Ravi K. Amaravadi,Lynn M. Schuchter,Hemant Ishwaran,Rosemarie Mick,Daniel A. Pryma,Xiaowei Xu,Michael Feldman,Tara C. Gangadhar,Stephen M. Hahn,E. John Wherry,Robert H. Vonderheide,Andy J. Minn +25 more
TL;DR: Major tumour regressions are reported in a subset of patients with metastatic melanoma treated with an anti-CTLA4 antibody and radiation and reproduced this effect in mouse models, showing that PD-L1 on melanoma cells allows tumours to escape anti- NCTLA4-based therapy, and the combination of radiation, anti- CTLA4 and anti-PD-L 1 promotes response and immunity through distinct mechanisms.
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Circulating CXCR5+PD-1+ Response Predicts Influenza Vaccine Antibody Responses in Young Adults but not Elderly Adults
Ramin S. Herati,Morgan A. Reuter,Douglas V. Dolfi,Kathleen D. Mansfield,Htin Aung,Osama Z. Badwan,Raj K. Kurupati,S. Kannan,Hildegund C.J. Ertl,Kenneth E. Schmader,Michael R. Betts,David H. Canaday,E. John Wherry +12 more
TL;DR: Future rational vaccine design efforts should incorporate Tfh measurement as an immune correlate of protection, particularly in the setting of aging.
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Persistent Enteric Murine Norovirus Infection is Associated with Functionally Suboptimal Virus-Specific CD8 T Cell Responses
Vesselin T. Tomov,Lisa C. Osborne,Douglas V. Dolfi,Gregory F. Sonnenberg,Laurel A. Monticelli,Kathleen D. Mansfield,Herbert W. Virgin,David Artis,E. John Wherry +8 more
TL;DR: In this article, the authors identified MNV-specific major histocompatibility complex (MHC) class I immunodominant epitopes using an overlapping peptide screen.
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Increased T-bet is associated with senescence of influenza virus-specific CD8 T cells in aged humans
Douglas V. Dolfi,Kathleen D. Mansfield,Antonio Polley,Susan A. Doyle,Gordon J. Freeman,Hanspeter Pircher,Kenneth E. Schmader,E. John Wherry +7 more
TL;DR: It is demonstrated that increased percentages of CD8 T cells from aged individuals express CD57 and KLRG1, along with PD‐1 and other inhibitory receptors, markers of senescence, or exhaustion, respectively, which suggest a prominent role forsenescence and/or terminal differentiation for influenza virus‐specific CD8T cells in elderly subjects.
Journal ArticleDOI
Vaccine-induced boosting of influenza virus-specific CD4 T cells in younger and aged humans.
Douglas V. Dolfi,Kathleen D. Mansfield,Raj K. Kurupati,S. Kannan,S. Kannan,Susan A. Doyle,Hildegund C.J. Ertl,Kenneth E. Schmader,E. John Wherry +8 more
TL;DR: Accumulation of pre-existing influenza virus-specific immunity in the form of NAb and cross-reactive T cells to conserved virus proteins over a lifetime of exposure to infection and vaccination may influence vaccine-induced CD4 T cell responses in the aged.