Katrina Podsypanina

TL;DR: An animal model has been developed in which the absence of Pten collaborates with Wnt-1 to induce ductal carcinoma in the mammary gland, useful for testing therapies specific for tumors deregulated in the PTEN/PI3K/AKT pathway.

TL;DR: The cellular and environmental context can lead to differential IL-6/pStat3 signaling and a dependency on this cytokine and transcription factor for migration, invasion and tumorigenesis.

TL;DR: A three-dimensional culture system is developed to analyze the responses of primary mouse mammary epithelial cells to the induction and deinduction of oncogenes and shows cells in the surviving spheres retain the ability to respond to reinduction and thus may represent the type of cells that give rise to recurrent tumors.

TL;DR: The results indicate that DNA mismatch repair deficiency can accelerate endometrial tumorigenesis in Pten heterozygous mice and suggests that loss of the wild-type Pten allele is involved in the development/progression of tumors in this setting.

TL;DR: This in vivo study uncovers an unexpected effect of ErbB2 activation previously known for its prosurvival roles, and suggests that protection of the ATM-mediated DDR-p53 signaling pathway may be important in breast cancer prevention.