L
Lionel B. Ivashkiv
Researcher at Hospital for Special Surgery
Publications - 191
Citations - 24055
Lionel B. Ivashkiv is an academic researcher from Hospital for Special Surgery. The author has contributed to research in topics: Signal transduction & Cytokine. The author has an hindex of 74, co-authored 177 publications receiving 19457 citations. Previous affiliations of Lionel B. Ivashkiv include Harvard University & Cornell University.
Papers
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Journal ArticleDOI
Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines
Peter J. Murray,Judith E. Allen,Subhra K. Biswas,Edward A. Fisher,Derek W. Gilroy,Sergij Goerdt,Siamon Gordon,John A. Hamilton,Lionel B. Ivashkiv,Toby Lawrence,Massimo Locati,Alberto Mantovani,Fernando O. Martinez,Jean-Louis Mege,David M. Mosser,Gioacchino Natoli,Jeroen P. J. Saeij,Joachim L. Schultze,Kari Ann Shirey,Antonio Sica,Jill Suttles,Irina A. Udalova,Jo A. Van Ginderachter,Stefanie N. Vogel,Thomas A. Wynn +24 more
TL;DR: A set of standards encompassing three principles-the source of macrophages, definition of the activators, and a consensus collection of markers to describe macrophage activation are described with the goal of unifying experimental standards for diverse experimental scenarios.
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Regulation of type I interferon responses
TL;DR: In this paper, the authors summarize the signalling and epigenetic mechanisms that regulate type I IFN-induced STAT activation and ISG transcription and translation and conclude that these regulatory mechanisms determine the biological outcomes of type I ILN responses and whether pathogens are cleared effectively or chronic infection or autoimmune disease ensues.
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TNF biology, pathogenic mechanisms and emerging therapeutic strategies
TL;DR: Molecular mechanisms underlying the roles of T NF in homeostasis and inflammatory disease pathogenesis are presented, and novel strategies to advance therapeutic paradigms for the treatment of TNF-mediated diseases are discussed.
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Cross-regulation of Signaling Pathways by Interferon-γ: Implications for Immune Responses and Autoimmune Diseases
TL;DR: Insights are revealed about how IFN-gamma regulates macrophage activation, inflammation, tissue remodeling, and helper and regulatory T cell differentiation and how Th1 and Th17 cell responses are integrated in autoimmune diseases.
Journal ArticleDOI
Pathologically expanded peripheral T helper cell subset drives B cells in rheumatoid arthritis
Deepak A. Rao,Michael F. Gurish,Jennifer L. Marshall,Kamil Slowikowski,Chamith Y. Fonseka,Yanyan Liu,Laura T. Donlin,Lauren A. Henderson,Kevin Wei,Fumitaka Mizoguchi,Nikola Teslovich,Nikola Teslovich,Michael E. Weinblatt,Elena Massarotti,Jonathan S. Coblyn,Simon M. Helfgott,Yvonne C. Lee,Derrick J. Todd,Vivian P. Bykerk,Susan M. Goodman,Susan M. Goodman,Alessandra B. Pernis,Lionel B. Ivashkiv,Elizabeth W. Karlson,Peter A. Nigrovic,Peter A. Nigrovic,Andrew Filer,Christopher D. Buckley,James A. Lederer,Soumya Raychaudhuri,Michael B. Brenner +30 more
TL;DR: Using multidimensional cytometry, transcriptomics, and functional assays, a population of PD-1hiCXCR5− ‘peripheral helper’ T (TPH) cells that express factors enabling B-cell help, including IL-21, CXCL13, ICOS, and MAF are defined.