M
Maria Teresa Sánchez-Aparicio
Researcher at Icahn School of Medicine at Mount Sinai
Publications - 26
Citations - 1807
Maria Teresa Sánchez-Aparicio is an academic researcher from Icahn School of Medicine at Mount Sinai. The author has contributed to research in topics: Interferon & Innate immune system. The author has an hindex of 17, co-authored 24 publications receiving 1296 citations. Previous affiliations of Maria Teresa Sánchez-Aparicio include Emerging Pathogens Institute & Spanish National Research Council.
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Journal ArticleDOI
SARS-CoV-2 Orf6 hijacks Nup98 to block STAT nuclear import and antagonize interferon signaling.
Lisa Miorin,Thomas Kehrer,Maria Teresa Sánchez-Aparicio,Ke Zhang,Phillip Cohen,Roosheel S. Patel,Anastasija Cupic,Tadashi Makio,Menghan Mei,Elena Moreno,Oded Danziger,Kris M. White,Raveen Rathnasinghe,Melissa B. Uccellini,Shengyan Gao,Teresa Aydillo,Ignacio Mena,Xin Yin,Laura Martin-Sancho,Nevan J. Krogan,Nevan J. Krogan,Nevan J. Krogan,Sumit K. Chanda,Michael Schotsaert,Richard W. Wozniak,Yi Ren,Brad R. Rosenberg,Beatriz M. A. Fontoura,Adolfo García-Sastre +28 more
TL;DR: SARS-CoV-2 is able to efficiently block STAT1 and STAT2 nuclear translocation in order to impair transcriptional induction of IFN-stimulated genes (ISGs).
Journal ArticleDOI
Dengue virus NS2B protein targets cGAS for degradation and prevents mitochondrial DNA sensing during infection.
Sebastian Aguirre,Priya Luthra,Maria Teresa Sánchez-Aparicio,Ana M. Maestre,Jenish R. Patel,Francise Lamothe,Anthony C. Fredericks,Shashank Tripathi,Tongtong Zhu,Jessica Pintado-Silva,Laurence G. Webb,Dabeiba Bernal-Rubio,Alexander Solovyov,Benjamin Greenbaum,Viviana Simon,Christopher F. Basler,Lubbertus C. F. Mulder,Adolfo García-Sastre,Ana Fernandez-Sesma +18 more
TL;DR: It is reported that the DENV NS2B protease cofactor targets the DNA sensor cyclic GMP-AMP synthase for lysosomal degradation to avoid the detection of mitochondrial DNA during infection and results in the inhibition of type I interferon production in the infected cell.
Journal ArticleDOI
The E3-Ligase TRIM Family of Proteins Regulates Signaling Pathways Triggered by Innate Immune Pattern-Recognition Receptors
Gijs A. Versteeg,Ricardo Rajsbaum,Maria Teresa Sánchez-Aparicio,Ana M. Maestre,Julio Valdiviezo,Mude Shi,Kyung-Soo Inn,Kyung-Soo Inn,Ana Fernandez-Sesma,Jae U. Jung,Adolfo García-Sastre +10 more
TL;DR: It is demonstrated that roughly half of the 75 TRIM-family members enhanced the innate immune response and that they do this at multiple levels in signaling pathways, which supports the notion that this family of proteins evolved as a component of innate immunity.
Journal ArticleDOI
Hijacking of RIG-I Signaling Proteins into Virus-Induced Cytoplasmic Structures Correlates with the Inhibition of Type I Interferon Responses
Felix W. Santiago,Lina M Covaleda,Maria Teresa Sánchez-Aparicio,Jesus A. Silvas,Ana C Diaz-Vizarreta,Jenish R. Patel,Vsevolod L. Popov,Xue Jie Yu,Adolfo García-Sastre,Patricia V. Aguilar +9 more
TL;DR: The data suggest that sequestration of RIG-I signaling molecules into endosome-like structures may be the mechanism used by SFTSV to inhibit IFN responses and point toward a novel mechanism for the suppression ofIFN responses.
Journal ArticleDOI
MERS-CoV 4b protein interferes with the NF-κB-dependent innate immune response during infection.
Javier Canton,Anthony R. Fehr,Raúl Fernandez-Delgado,Francisco J. Gutierrez-Alvarez,Maria Teresa Sánchez-Aparicio,Adolfo García-Sastre,Stanley Perlman,Luis Enjuanes,Isabel Sola +8 more
TL;DR: It is found that MERS-CoV 4b was required to prevent a robust NF-κB dependent response during infection, and a model where 4b outcompetes NF-α4 for KPNA4 binding and translocation into the nucleus as a mechanism of interference with the NF-σκB-mediated innate immune response is proposed.