Kebin Huang

TL;DR: Findings identify a non-immune checkpoint function of PD-L1 and provide an unexpected concept that GSDMC/Caspas-8 mediates non-canonical pyroptosis pathway in cancer cells, causing tumor necrosis.

TL;DR: An endoplasmic reticulum stress-inducing cyclometalated Ir(III)-bisNHC complex (1a) is reported as a new ICD inducer, and based on this compound, a clickable photoaffinity probe was designed for target identification, which unveiled the engagement of the master regulator protein BiP of the unfolded protein response pathway.

TL;DR: Xia et al. as mentioned in this paper showed that LXN deficiency increases hematopoietic stem cells, as well as affects the proportion of immune cells in the peripheral system.

TL;DR: In this article , the authors explored the nuclear export signal (NES) sequence of EGFR that is responsible for interacting with the exportins, and they combined in silico prediction with site-directed mutagenesis approaches and identified a putative NES motif, which is located in amino acid residues 736-749.