L
Lei Nie
Researcher at University of Texas MD Anderson Cancer Center
Publications - 31
Citations - 1252
Lei Nie is an academic researcher from University of Texas MD Anderson Cancer Center. The author has contributed to research in topics: Medicine & Cancer research. The author has an hindex of 11, co-authored 15 publications receiving 627 citations.
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Journal ArticleDOI
PD-L1-mediated gasdermin C expression switches apoptosis to pyroptosis in cancer cells and facilitates tumour necrosis
Junwei Hou,Rongce Zhao,Rongce Zhao,Rongce Zhao,Weiya Xia,Chiung Wen Chang,Yun You,Jung Mao Hsu,Jung Mao Hsu,Lei Nie,Yeh Chen,Yu Chuan Wang,Chunxiao Liu,Wei Jan Wang,Wei Jan Wang,Yun Wu,Baozhen Ke,Jennifer L. Hsu,Kebin Huang,Kebin Huang,Zu Ye,Yi Yang,Xianghou Xia,Yintao Li,Chia Wei Li,Bin Shao,Bin Shao,John A. Tainer,Mien Chie Hung,Mien Chie Hung,Mien Chie Hung +30 more
TL;DR: Findings identify a non-immune checkpoint function of PD-L1 and provide an unexpected concept that GSDMC/Caspas-8 mediates non-canonical pyroptosis pathway in cancer cells, causing tumor necrosis.
Journal Article
Long non-coding RNAs: versatile master regulators of gene expression and crucial players in cancer
Lei Nie,Hsing Ju Wu,Jung Mao Hsu,Shih Shin Chang,Adam M. Labaff,Chia Wei Li,Yan Wang,Jennifer L. Hsu,Jennifer L. Hsu,Jennifer L. Hsu,Mien Chie Hung +10 more
TL;DR: The regulatory function of LNCRNAs is summarized with a particular focus on the underlying mechanisms of LncRNAs in oncogenesis, tumor metastasis and suppression.
Journal ArticleDOI
IL-6/JAK1 pathway drives PD-L1 Y112 phosphorylation to promote cancer immune evasion.
Li Chuan Chan,Chia Wei Li,Weiya Xia,Jung Mao Hsu,Heng Huan Lee,Jong Ho Cha,Jong Ho Cha,Hung Ling Wang,Wen Hao Yang,Er Yen Yen,Wei Chao Chang,Zhengyu Zha,Seung Oe Lim,Yun-Ju Lai,Chunxiao Liu,Jielin Liu,Jielin Liu,Qiongzhu Dong,Qiongzhu Dong,Yi Yang,Linlin Sun,Linlin Sun,Yongkun Wei,Lei Nie,Jennifer L. Hsu,Jennifer L. Hsu,Jennifer L. Hsu,Hui Li,Hui Li,Qing-Hai Ye,Manal M. Hassan,Hesham M. Amin,Ahmed Kaseb,Xin Lin,Shao Chun Wang,Mien Chie Hung +35 more
TL;DR: It is shown that IL-6-activated JAK1 phosphorylates programmed death-ligand 1 (PD-L 1) Tyr112, which recruits the endoplasmic reticulum-associated N-glycosyltransferase STT3A to catalyze PD-L1 glycosylation and maintain PD- L1 stability.
Journal ArticleDOI
EZH2 contributes to the response to PARP inhibitors through its PARP-mediated poly-ADP ribosylation in breast cancer
Hirohito Yamaguchi,Yi Du,Katsuya Nakai,Ming Ding,Shih Shin Chang,Jennifer L. Hsu,Jun Yao,Yongkun Wei,Lei Nie,Shiping Jiao,Wei Chao Chang,Wei Chao Chang,Chung-Hsuan Chen,Yonghao Yu,Gabriel N. Hortobagyi,Mien Chie Hung,Mien Chie Hung,Mien Chie Hung +17 more
TL;DR: In this article, an enhancer of zeste homolog 2 (EZH2), an enzyme that catalyzes H3 lysine trimethylation and associates with oncogenic function, contributes to PARPi sensitivity in breast cancer cells.
Journal ArticleDOI
CDK2-mediated site-specific phosphorylation of EZH2 drives and maintains triple-negative breast cancer.
Lei Nie,Yongkun Wei,Fei Zhang,Fei Zhang,Yi Hsin Hsu,Li Chuan Chan,Li Chuan Chan,Weiya Xia,Baozhen Ke,Cihui Zhu,Rong Deng,Rong Deng,Jun Tang,Jun Tang,Jun Yao,Yu Yi Chu,Xixi Zhao,Xixi Zhao,Ye Han,Ye Han,Junwei Hou,Longfei Huo,How Wen Ko,How Wen Ko,Wan Chi Lin,Hirohito Yamaguchi,Hirohito Yamaguchi,Jung-Mao Hsu,Yi Yang,Dean N. Pan,Dean N. Pan,Jennifer L. Hsu,Jennifer L. Hsu,Jennifer L. Hsu,Celina G. Kleer,Nancy E. Davidson,Gabriel N. Hortobagyi,Mien Chie Hung +37 more
TL;DR: It is shown that this signaling axis downregulates ERα, and thus combinatorial blockade of CDK2 and EZH2 sensitizes TNBC cells to tamoxifen.