K
Keisuke Okita
Researcher at Kyoto University
Publications - 115
Citations - 26472
Keisuke Okita is an academic researcher from Kyoto University. The author has contributed to research in topics: Induced pluripotent stem cell & Embryonic stem cell. The author has an hindex of 46, co-authored 110 publications receiving 24423 citations. Previous affiliations of Keisuke Okita include Kumamoto University & Hokkaido University.
Papers
More filters
Journal ArticleDOI
Transplantation of mouse induced pluripotent stem cells into the cochlea.
Koji Nishimura,Takayuki Nakagawa,Kazuya Ono,Hideaki Ogita,Tatsunori Sakamoto,Norio Yamamoto,Keisuke Okita,Shinya Yamanaka,Juichi Ito +8 more
TL;DR: Findings indicate that iPS cells can be used as a source of transplants for the regeneration of spiral ganglion neurons.
Journal ArticleDOI
Rewinding the process of mammalian extinction.
Joseph Saragusty,Sebastian Diecke,Micha Drukker,Barbara S. Durrant,Inbar Friedrich Ben-Nun,Cesare Galli,Frank Göritz,Katsuhiko Hayashi,Robert Hermes,Susanne Holtze,Stacey Johnson,Giovanna Lazzari,Pasqualino Loi,Jeanne F. Loring,Keisuke Okita,Marilyn B. Renfree,Steven Seet,Thomas Voracek,Jan Stejskal,Oliver A. Ryder,Thomas B. Hildebrandt +20 more
TL;DR: The ideas discussed here, while centered on the northern white rhinoceros, are equally applicable, after proper adjustments, to other mammals on the brink of extinction.
Journal ArticleDOI
Hybrid Cellular Metabolism Coordinated by Zic3 and Esrrb Synergistically Enhances Induction of Naive Pluripotency
Masamitsu Sone,Nobuhiro Morone,Nobuhiro Morone,Tomonori Nakamura,Akito Tanaka,Keisuke Okita,Knut Woltjen,Masato Nakagawa,John E. Heuser,Yasuhiro Yamada,Shinya Yamanaka,Takuya Yamamoto +11 more
TL;DR: This study suggests that the combinatorial function of TFs achieves an appropriate balance of metabolic pathways to induce naive PSCs, and synergistically enhance the reprogramming efficiency by regulating cellular metabolic pathways.
Journal ArticleDOI
Spred-2 Suppresses Aorta-Gonad-Mesonephros Hematopoiesis by Inhibiting MAP Kinase Activation
Ikuo Nobuhisa,Reiko Kato,Hirofumi Inoue,Makiko Takizawa,Keisuke Okita,Akihiko Yoshimura,Tetsuya Taga +6 more
TL;DR: It is shown that a Ras/mitogen-activated protein (MAP) kinase signaling-specific inhibitor and a dominant negative mutant Ras blocked the production of CD45+ hematopoietic cells in embryonic day 11.5 AGM culture, indicating an essential role for the MAP kinase pathway in AGM hematoiesis.
Journal ArticleDOI
OVOL2 Maintains the Transcriptional Program of Human Corneal Epithelium by Suppressing Epithelial-to-Mesenchymal Transition.
Koji Kitazawa,Takafusa Hikichi,Takahiro Nakamura,Kanae Mitsunaga,Azusa Tanaka,Masahiro Nakamura,Tatsuya Yamakawa,Shiori Furukawa,Mieko Takasaka,Naoki Goshima,Akira Watanabe,Keisuke Okita,Satoshi Kawasaki,Satoshi Kawasaki,Morio Ueno,Shigeru Kinoshita,Shinji Masui +16 more
TL;DR: It is shown that the transcription factor O VOL2 maintains the transcriptional program of human corneal epithelium cells (CECs), a derivative of the surface ectoderm, and that OVOL2 may regulate the differential transcriptional programs of the two lineages.